Differential regional expression of genes in the developing brain of Ciona intestinalis embryos

Naoki Shimozono, Naoyuki Ohta, Nori Satoh, Mayuko Hamada

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Our previous transcriptome analysis identified 565 genes that are preferentially expressed in the developing brain of Ciona intestinalis larvae. Here, we show by in-situ hybridization that the spatial expression patterns of these brain-specific genes fall into different categories depending on the regions where the gene is expressed. For example, Ci-opsin3 and Ci-Dkk3 are expressed in the entire brain, Ci-tyrosinase and Ci-TYRP1 in the dorsal region, and Ci-synaptotagmin3, Ci-ZF399, and Ci-PTFb in the ventral region. Other genes are specific to the posterior, anterior, central, posterior and ventral, or anterior-ventral region of the brain. This regional expression of genes in the Ciona brain is not always associated with cell lineage, suggesting that complex mechanisms control the regionalized expression of brain-specific genes.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalZoological Science
Volume27
Issue number2
DOIs
Publication statusPublished - Feb 2010
Externally publishedYes

Fingerprint

embryo (animal)
brain
gene expression
genes
transcriptomics
in situ hybridization
Ciona intestinalis
larvae
cells

Keywords

  • Ciona intestinalis
  • Developing brain
  • Differential spatial expression
  • Specific genes

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Differential regional expression of genes in the developing brain of Ciona intestinalis embryos. / Shimozono, Naoki; Ohta, Naoyuki; Satoh, Nori; Hamada, Mayuko.

In: Zoological Science, Vol. 27, No. 2, 02.2010, p. 103-109.

Research output: Contribution to journalArticle

Shimozono, Naoki ; Ohta, Naoyuki ; Satoh, Nori ; Hamada, Mayuko. / Differential regional expression of genes in the developing brain of Ciona intestinalis embryos. In: Zoological Science. 2010 ; Vol. 27, No. 2. pp. 103-109.
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