Differential induction of interleukin-I β mRNA in the brain parenchyma of Lewis and Fischer rats after peripheral injection of lipopolysaccharides

Leonardo H. Tonelli, Shigeru Maeda, Kimberly L. Rapp, Esther M. Sternberg

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The expression of interleukin-1 beta (IL-1β) mRNA was compared in the brain of inflammatory susceptible LEW/N and resistant F344/N rats at 3, 6, and 12 h after peripheral administration of lipopolysaccharide (LPS) or saline. No differences between strains were observed in the circumventricular organs (CVOs) and choroid plexus. At 12 h after LPS administration, increased IL-1β mRNA expression was detected in the hypothalamus of LEW/N rats. In contrast, increased IL-1β mRNA expression was detected in the cerebral cortex of F344/N rats. These data show region-specific differences of IL-1β mRNA expression in the brain of these rat strains that differ in their susceptibility to inflammation.

Original languageEnglish
Pages (from-to)126-136
Number of pages11
JournalJournal of Neuroimmunology
Volume140
Issue number1-2
DOIs
Publication statusPublished - Jul 2003
Externally publishedYes

Fingerprint

Inbred F344 Rats
Interleukin-1beta
Interleukin-1
Lipopolysaccharides
Messenger RNA
Injections
Brain
Choroid Plexus
Cerebral Cortex
Hypothalamus
Inflammation

Keywords

  • Cerebral cortex
  • Circumventricular organs
  • Cytokines
  • Hypothalamus
  • Inbred rats

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Differential induction of interleukin-I β mRNA in the brain parenchyma of Lewis and Fischer rats after peripheral injection of lipopolysaccharides. / Tonelli, Leonardo H.; Maeda, Shigeru; Rapp, Kimberly L.; Sternberg, Esther M.

In: Journal of Neuroimmunology, Vol. 140, No. 1-2, 07.2003, p. 126-136.

Research output: Contribution to journalArticle

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