Differential induction of interleukin-I β mRNA in the brain parenchyma of Lewis and Fischer rats after peripheral injection of lipopolysaccharides

Leonardo H. Tonelli, Shigeru Maeda, Kimberly L. Rapp, Esther M. Sternberg

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21 Citations (Scopus)


The expression of interleukin-1 beta (IL-1β) mRNA was compared in the brain of inflammatory susceptible LEW/N and resistant F344/N rats at 3, 6, and 12 h after peripheral administration of lipopolysaccharide (LPS) or saline. No differences between strains were observed in the circumventricular organs (CVOs) and choroid plexus. At 12 h after LPS administration, increased IL-1β mRNA expression was detected in the hypothalamus of LEW/N rats. In contrast, increased IL-1β mRNA expression was detected in the cerebral cortex of F344/N rats. These data show region-specific differences of IL-1β mRNA expression in the brain of these rat strains that differ in their susceptibility to inflammation.

Original languageEnglish
Pages (from-to)126-136
Number of pages11
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - Jul 2003



  • Cerebral cortex
  • Circumventricular organs
  • Cytokines
  • Hypothalamus
  • Inbred rats

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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