Differential expression of three chick FGF receptor genes, FGFR1, FGFR2 and FGFR3, in limb and feather development.

S. Noji, E. Koyama, F. Myokai, T. Nohno, Hideyo Ohuchi, K. Nishikawa, S. Taniguchi

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Expression patterns of three fibroblast growth factor receptor genes, FGFR1 (cek1), FGFR2 (cek3) and FGFR3 (cek2), were observed in limb and feather morphogenesis. Expression of FGFR1 was observed in the mesoderm of limb bud, in the mesenchyme just underneath the feather placode, and then in the anterior mesenchyme of the feather bud. While expression of FGFR2 was observed in both surface ectoderm and mesenchymal aggregates corresponding to the future bones of the limb, the mesenchyme between the feather placode, and surface ectoderm of feather buds. Expression of FGFR3 was observed rather ubiquitously over mesoderm of limb and feather buds. Differential expression of these FGF receptor genes suggested that differential roles of these receptors in epithelia-mesenchymal interactions of limb and feather morphogenesis.

Original languageEnglish
Pages (from-to)645-654
Number of pages10
JournalProgress in Clinical and Biological Research
Volume383 B
Publication statusPublished - 1993

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Fibroblast Growth Factor Receptors
Feathers
Extremities
Mesoderm
Genes
Limb Buds
Ectoderm
Morphogenesis
Epithelium
Bone and Bones

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Differential expression of three chick FGF receptor genes, FGFR1, FGFR2 and FGFR3, in limb and feather development. / Noji, S.; Koyama, E.; Myokai, F.; Nohno, T.; Ohuchi, Hideyo; Nishikawa, K.; Taniguchi, S.

In: Progress in Clinical and Biological Research, Vol. 383 B, 1993, p. 645-654.

Research output: Contribution to journalArticle

Noji, S. ; Koyama, E. ; Myokai, F. ; Nohno, T. ; Ohuchi, Hideyo ; Nishikawa, K. ; Taniguchi, S. / Differential expression of three chick FGF receptor genes, FGFR1, FGFR2 and FGFR3, in limb and feather development. In: Progress in Clinical and Biological Research. 1993 ; Vol. 383 B. pp. 645-654.
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AU - Nohno, T.

AU - Ohuchi, Hideyo

AU - Nishikawa, K.

AU - Taniguchi, S.

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