Differential Expression of S100C in Thyroid Lesions

Carlos Torres-Cabala, Angel Panizo-Santos, Henry C. Krutzsch, Heba Barazi, Masayoshi Namba, Masakiyo Sakaguchi, David D. Roberts, Maria J. Merino

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Identification of new potential markers that may help in the diagnosis of benign and malignant thyroid lesions is needed. By comparative 2-dimensional gel electrophoresis of microdissected cells from tumors and normal thyroid tissue, we identified a new protein, S100C, which is highly expressed in papillary carcinomas. In order to validate this finding, we investigated the immunohistochemical expression and the potential role in diagnosis of these markers in 94 specimens representing the spectrum of malignant and benign thyroid lesions. Normal thyroid tissue was evaluated in 57 specimens. Galectin-3, a marker reported as specific for malignant lesions, was also evaluated in the same lesions. S100C protein was expressed in the nuclei of normal tissue, hyperplastic nodules, and follicular adenomas and carcinomas. Papillary carcinomas showed a strong, but cytoplasmic, pattern of staining. Galectin-3 immunostaining was strongly positive in papillary carcinomas, and negative in benign lesions, confirming its value in differential diagnosis. These findings suggest that immunohistochemical staining of S100C could be helpful in the pathological study of thyroid lesions, especially in cases in which follicular variants of papillary carcinoma and follicular carcinoma are considered in the differential diagnosis.

Original languageEnglish
Pages (from-to)107-115
Number of pages9
JournalInternational Journal of Surgical Pathology
Volume12
Issue number2
DOIs
Publication statusPublished - Apr 1 2004

Keywords

  • Calgizzarin
  • Galectin-3
  • Immunohistochemistry
  • Proteomics
  • S100C
  • Thyroid

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Differential Expression of S100C in Thyroid Lesions'. Together they form a unique fingerprint.

  • Cite this

    Torres-Cabala, C., Panizo-Santos, A., Krutzsch, H. C., Barazi, H., Namba, M., Sakaguchi, M., Roberts, D. D., & Merino, M. J. (2004). Differential Expression of S100C in Thyroid Lesions. International Journal of Surgical Pathology, 12(2), 107-115. https://doi.org/10.1177/106689690401200203