Differential expression of homeobox-containing genes Msx-1 and Msx-2 and homeoprotein Msx-2 expression during chick craniofacial development

K. Nishikawa, T. Nakanishi, Chiharu Sogawa, Takako Hattori, K. Takahashi, S. Taniguchi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The expression pattern of chick Msx-1 and Msx-2 homeobox genes in craniofacial primordia was examined by in situ hybridization using cRNA probes. Both genes were expressed in the distal region of the facial primordia, where the distribution of Msx-2 expression was restricted distally within the Msx-1 expression domain. On the contrary, Msx-2 expression in the lateral choroid plexus and cranial skull was broader and more intensive than Msx-1 expression. Our findings suggest that these two genes cooperate to play differential roles in craniofacial development. Msx-2 protein was detected immunohistochemically, and its localization essentially corresponded to the mRNA expression pattern, substantiating the involvement of Msx-2 protein as a transcriptional regulator in developing limb and face.

Original languageEnglish
Pages (from-to)763-771
Number of pages9
JournalBiochemistry and Molecular Biology International
Volume32
Issue number4
Publication statusPublished - 1994

Fingerprint

Homeodomain Proteins
Homeobox Genes
Genes
Complementary RNA
Choroid Plexus
Skull
In Situ Hybridization
Proteins
Extremities
Messenger RNA

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Molecular Biology

Cite this

Differential expression of homeobox-containing genes Msx-1 and Msx-2 and homeoprotein Msx-2 expression during chick craniofacial development. / Nishikawa, K.; Nakanishi, T.; Sogawa, Chiharu; Hattori, Takako; Takahashi, K.; Taniguchi, S.

In: Biochemistry and Molecular Biology International, Vol. 32, No. 4, 1994, p. 763-771.

Research output: Contribution to journalArticle

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