Differential expression of Fos protein after transection of the rat infraorbital nerve in the trigeminal nucleus caudalis

Ryuji Terayama, Nahoko Nagamatsu, Tetsuya Ikeda, Tadashi Nakamura, Omar I F Rahman, Sumio Sakoda, Ryosuke Shiba, Toshikazu Nishimori

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

To determine the effects of nerve injury on Fos expression, temporal and spatial distributions of Fos-positive neurons in the trigeminal nucleus caudalis were examined after tissue injury for isolation of the infraorbital nerve as controls and transection of this nerve as well as noxious chemical stimulation by formalin injection in adult rats. Fos immunoreactivity was markedly elevated in laminae I and II of the only ipsilateral nucleus caudalis 2 h after these surgical procedures and noxious chemical stimulation. The distributions of Fos-positive neurons were restricted rostro-caudally following formalin injection and tissue injury compared to transection of the infraorbital nerve. One day after tissue injury and nerve transection, however, Fos-positive neurons were distributed bilaterally in laminae III and IV extending rostro-caudally and medio-laterally in this nucleus, and this persisted over the 2-week study period. The number of Fos- positive neurons in the side ipsilateral to nerve transection was markedly less than that in the contralateral side whereas positive neurons in the tissue injured rats were distributed symmetrically along the rostro-caudal axis. There was no difference in the contralateral sides between nerve transection and tissue injury groups. The rostro-caudal level showing reduction in Fos expression corresponded roughly to the sites of central termination of the injured nerve in this nucleus, suggesting a role for the primary afferents in the reduction of Fos expression in laminae III and IV neurons of the ipsilateral nucleus caudalis.

Original languageEnglish
Pages (from-to)135-146
Number of pages12
JournalBrain Research
Volume768
Issue number1-2
DOIs
Publication statusPublished - Sep 12 1997
Externally publishedYes

Fingerprint

Trigeminal Nuclei
Neurons
Chemical Stimulation
Wounds and Injuries
Nerve Tissue
Proteins
Formaldehyde
Substantia Gelatinosa
Injections
Spinal Cord Dorsal Horn

Keywords

  • Fos
  • Immunohistochemistry
  • Infraorbital nerve
  • Nerve injury
  • Tissue injury
  • Trigeminal nucleus caudalis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Terayama, R., Nagamatsu, N., Ikeda, T., Nakamura, T., Rahman, O. I. F., Sakoda, S., ... Nishimori, T. (1997). Differential expression of Fos protein after transection of the rat infraorbital nerve in the trigeminal nucleus caudalis. Brain Research, 768(1-2), 135-146. https://doi.org/10.1016/S0006-8993(97)00633-1

Differential expression of Fos protein after transection of the rat infraorbital nerve in the trigeminal nucleus caudalis. / Terayama, Ryuji; Nagamatsu, Nahoko; Ikeda, Tetsuya; Nakamura, Tadashi; Rahman, Omar I F; Sakoda, Sumio; Shiba, Ryosuke; Nishimori, Toshikazu.

In: Brain Research, Vol. 768, No. 1-2, 12.09.1997, p. 135-146.

Research output: Contribution to journalArticle

Terayama, R, Nagamatsu, N, Ikeda, T, Nakamura, T, Rahman, OIF, Sakoda, S, Shiba, R & Nishimori, T 1997, 'Differential expression of Fos protein after transection of the rat infraorbital nerve in the trigeminal nucleus caudalis', Brain Research, vol. 768, no. 1-2, pp. 135-146. https://doi.org/10.1016/S0006-8993(97)00633-1
Terayama, Ryuji ; Nagamatsu, Nahoko ; Ikeda, Tetsuya ; Nakamura, Tadashi ; Rahman, Omar I F ; Sakoda, Sumio ; Shiba, Ryosuke ; Nishimori, Toshikazu. / Differential expression of Fos protein after transection of the rat infraorbital nerve in the trigeminal nucleus caudalis. In: Brain Research. 1997 ; Vol. 768, No. 1-2. pp. 135-146.
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