Differential expression of canonical and non-canonical Wnt ligands in ameloblastoma

Chong Huat Siar, Hitoshi Nagatsuka, Phuu Pwint Han, Rosario Rivera Buery, Hidetsugu Tsujigiwa, Keisuke Nakano, Kok Han Ng, Toshiyuki Kawakami

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: Canonical and non-canonical Wnt signaling pathways modulate diverse cellular processes during embryogenesis and post-natally. Their deregulations have been implicated in cancer development and progression. Wnt signaling is essential for odontogenesis. The ameloblastoma is an odontogenic epithelial neoplasm of enamel organ origin. Altered expressions of Wnts-1, -2, -5a, and -10a are detected in this tumor. The activity of other Wnt members remains unclarified. Materials and Methods: Canonical (Wnts-1, -2, -3, -8a, -8b, -10a, and -10b), non-canonical (Wnts-4, -5a, -5b, -6, 7a, -7b, and -11), and indeterminate groups (Wnts-2b and -9b) were examined immunohistochemically in 72 cases of ameloblastoma (19 unicystic [UA], 35 solid/multicystic [SMA], eight desmoplastic [DA], and 10 recurrent [RA]). Results: Canonical Wnt proteins (except Wnt-10b) were heterogeneously expressed in ameloblastoma. Their distribution patterns were distinctive with some overlap. Protein localization was mainly membranous and/or cytoplasmic. Overexpression of Wnt-1 in most subsets (UA=19/19; SMA=35/35; DA=5/8; RA= 7/10) (P

Original languageEnglish
Pages (from-to)332-339
Number of pages8
JournalJournal of Oral Pathology and Medicine
Volume41
Issue number4
DOIs
Publication statusPublished - Apr 2012

Fingerprint

Ameloblastoma
Ligands
Odontogenesis
Enamel Organ
Wnt Proteins
Wnt Signaling Pathway
Glandular and Epithelial Neoplasms
Embryonic Development
Neoplasms
Proteins

Keywords

  • Ameloblastoma
  • Canonical
  • Immunohistochemistry
  • Non-canonical
  • Wnt

ASJC Scopus subject areas

  • Cancer Research
  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oral Surgery
  • Periodontics

Cite this

Differential expression of canonical and non-canonical Wnt ligands in ameloblastoma. / Siar, Chong Huat; Nagatsuka, Hitoshi; Han, Phuu Pwint; Buery, Rosario Rivera; Tsujigiwa, Hidetsugu; Nakano, Keisuke; Ng, Kok Han; Kawakami, Toshiyuki.

In: Journal of Oral Pathology and Medicine, Vol. 41, No. 4, 04.2012, p. 332-339.

Research output: Contribution to journalArticle

Siar, Chong Huat ; Nagatsuka, Hitoshi ; Han, Phuu Pwint ; Buery, Rosario Rivera ; Tsujigiwa, Hidetsugu ; Nakano, Keisuke ; Ng, Kok Han ; Kawakami, Toshiyuki. / Differential expression of canonical and non-canonical Wnt ligands in ameloblastoma. In: Journal of Oral Pathology and Medicine. 2012 ; Vol. 41, No. 4. pp. 332-339.
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