Differential effects of adenosine on histamine secretion induced by antigen and chemical stimuli

Masahiro Nishibori, K. Shimamura, H. Yokoyama, K. Tsutsumi, K. Saeki

Research output: Contribution to journalArticle

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Abstract

Adenosine had a dual effect on the IgE-mediated histamine secretion from rat peritoneal mast cells: an inhibition at relatively low concentrations and a potentiation at higher concentrations. An adenosine R-site analog, N6-methyladenosine, had a similar dual effect while adenosine P-site analogs, 9-β-D-arabinofuranosyladenine and 2'-deoxyadenosine, had neither inhibitory nor potentiating effects. Both compound 48/80- and α-chymotrypsin-induced histamine secretion were dose-dependently inhibited by adenosine. Not only R- and P-site analogs of adenosine but also a wide variety of purine and pyrimidine derivatives such as adenine, AMP, cyclic AMP, ADP, guanosine, inosine and cytosine showed inhibitory activities on the compound 48/80-induced histamine secretion. Adenosine had no influence on substance P- and neurotensin-induced histamine secretion.

Original languageEnglish
Pages (from-to)17-28
Number of pages12
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume265
Issue number1
Publication statusPublished - 1983

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Adenosine
Histamine
Antigens
p-Methoxy-N-methylphenethylamine
Vidarabine
Neurotensin
Inosine
Guanosine
Cytosine
Chymotrypsin
Adenine
Adenosine Monophosphate
Substance P
Mast Cells
Cyclic AMP
Adenosine Diphosphate
Immunoglobulin E

ASJC Scopus subject areas

  • Pharmacology

Cite this

Differential effects of adenosine on histamine secretion induced by antigen and chemical stimuli. / Nishibori, Masahiro; Shimamura, K.; Yokoyama, H.; Tsutsumi, K.; Saeki, K.

In: Archives Internationales de Pharmacodynamie et de Therapie, Vol. 265, No. 1, 1983, p. 17-28.

Research output: Contribution to journalArticle

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