Differential effects of adenosine on histamine secretion induced by antigen and chemical stimuli

M. Nishibori, K. Shimamura, H. Yokoyama, K. Tsutsumi, K. Saeki

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Adenosine had a dual effect on the IgE-mediated histamine secretion from rat peritoneal mast cells: an inhibition at relatively low concentrations and a potentiation at higher concentrations. An adenosine R-site analog, N6-methyladenosine, had a similar dual effect while adenosine P-site analogs, 9-β-D-arabinofuranosyladenine and 2'-deoxyadenosine, had neither inhibitory nor potentiating effects. Both compound 48/80- and α-chymotrypsin-induced histamine secretion were dose-dependently inhibited by adenosine. Not only R- and P-site analogs of adenosine but also a wide variety of purine and pyrimidine derivatives such as adenine, AMP, cyclic AMP, ADP, guanosine, inosine and cytosine showed inhibitory activities on the compound 48/80-induced histamine secretion. Adenosine had no influence on substance P- and neurotensin-induced histamine secretion.

Original languageEnglish
Pages (from-to)17-28
Number of pages12
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume265
Issue number1
Publication statusPublished - Dec 1 1983

ASJC Scopus subject areas

  • Pharmacology

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