Differential effect of prostaglandins E1 and E2 on lipopolysaccharide-induced adhesion molecule expression on human monocytes

Hideo K. Takahashi, Hiromi Iwagaki, Ryuji Tamura, Goutaro Katsuno, Dong Xue, Sachi Sugita, Shuji Mori, Tadashi Yoshino, Noriaki Tanaka, Masahiro Nishibori

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The effect of prostaglandins E1 and E2 on the 1 ng/ml lipopolysaccharide-induced expression of intercellular adhesion molecule (ICAM)-1, B7.1, B7.2, CD40 and CD40 ligand (CD40L) on monocytes was examined. Prostaglandin E1 suppressed B7.1 and CD40 expression, but prostaglandin E2 did not effect on any type of adhesion molecule expression. Both prostaglandins inhibited tumor necrosis factor (TNF)-α production and T-cell proliferation of lipopolysaccharide-treated human peripheral blood mononuclear cells (PBMC). Among prostaglandin E1 receptors (IP/EP1/EP2/EP3/EP4) agonists, ONO-1301, a prostanoid IP-receptor agonist, prevented B7.1 and CD40 expression. ONO-AE1-259-01 a prostanoid EP2-receptor agonist, ONO-AE1-329, a prostanoid EP4-receptor agonist, and ONO-1301 inhibited TNF-α production and T-cell proliferation. Moreover, anti-B7.1 and anti-CD40 Abs prevented lipopolysaccharide-induced TNF-α production and T-cell proliferation. Therefore, the effect of prostaglandin E1 on TNF-α production and T-cell proliferation might depend on the inhibition of B7.1 and CD40 expression, but that of prostaglandin E2 might be independent of adhesion molecules expression. In conclusion, the mechanism responsible for the effect of prostaglandin E1 on lipopolysaccharide-induced responses is distinct from that of prostaglandin E2.

Original languageEnglish
Pages (from-to)223-230
Number of pages8
JournalEuropean Journal of Pharmacology
Volume512
Issue number2-3
DOIs
Publication statusPublished - Apr 11 2005

Fingerprint

Alprostadil
Dinoprostone
Lipopolysaccharides
Monocytes
Tumor Necrosis Factor-alpha
Cell Proliferation
T-Lymphocytes
Prostaglandins
Receptors, Prostaglandin E, EP2 Subtype
Receptors, Prostaglandin E, EP4 Subtype
Prostaglandin Receptors
CD40 Ligand
Intercellular Adhesion Molecule-1
Blood Cells
ONO 1301

Keywords

  • Adhesion molecule
  • Monocyte
  • Prostaglandin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Differential effect of prostaglandins E1 and E2 on lipopolysaccharide-induced adhesion molecule expression on human monocytes. / Takahashi, Hideo K.; Iwagaki, Hiromi; Tamura, Ryuji; Katsuno, Goutaro; Xue, Dong; Sugita, Sachi; Mori, Shuji; Yoshino, Tadashi; Tanaka, Noriaki; Nishibori, Masahiro.

In: European Journal of Pharmacology, Vol. 512, No. 2-3, 11.04.2005, p. 223-230.

Research output: Contribution to journalArticle

Takahashi, Hideo K. ; Iwagaki, Hiromi ; Tamura, Ryuji ; Katsuno, Goutaro ; Xue, Dong ; Sugita, Sachi ; Mori, Shuji ; Yoshino, Tadashi ; Tanaka, Noriaki ; Nishibori, Masahiro. / Differential effect of prostaglandins E1 and E2 on lipopolysaccharide-induced adhesion molecule expression on human monocytes. In: European Journal of Pharmacology. 2005 ; Vol. 512, No. 2-3. pp. 223-230.
@article{80e0b5e0147c425ab3f6b5ee75214691,
title = "Differential effect of prostaglandins E1 and E2 on lipopolysaccharide-induced adhesion molecule expression on human monocytes",
abstract = "The effect of prostaglandins E1 and E2 on the 1 ng/ml lipopolysaccharide-induced expression of intercellular adhesion molecule (ICAM)-1, B7.1, B7.2, CD40 and CD40 ligand (CD40L) on monocytes was examined. Prostaglandin E1 suppressed B7.1 and CD40 expression, but prostaglandin E2 did not effect on any type of adhesion molecule expression. Both prostaglandins inhibited tumor necrosis factor (TNF)-α production and T-cell proliferation of lipopolysaccharide-treated human peripheral blood mononuclear cells (PBMC). Among prostaglandin E1 receptors (IP/EP1/EP2/EP3/EP4) agonists, ONO-1301, a prostanoid IP-receptor agonist, prevented B7.1 and CD40 expression. ONO-AE1-259-01 a prostanoid EP2-receptor agonist, ONO-AE1-329, a prostanoid EP4-receptor agonist, and ONO-1301 inhibited TNF-α production and T-cell proliferation. Moreover, anti-B7.1 and anti-CD40 Abs prevented lipopolysaccharide-induced TNF-α production and T-cell proliferation. Therefore, the effect of prostaglandin E1 on TNF-α production and T-cell proliferation might depend on the inhibition of B7.1 and CD40 expression, but that of prostaglandin E2 might be independent of adhesion molecules expression. In conclusion, the mechanism responsible for the effect of prostaglandin E1 on lipopolysaccharide-induced responses is distinct from that of prostaglandin E2.",
keywords = "Adhesion molecule, Monocyte, Prostaglandin",
author = "Takahashi, {Hideo K.} and Hiromi Iwagaki and Ryuji Tamura and Goutaro Katsuno and Dong Xue and Sachi Sugita and Shuji Mori and Tadashi Yoshino and Noriaki Tanaka and Masahiro Nishibori",
year = "2005",
month = "4",
day = "11",
doi = "10.1016/j.ejphar.2005.01.046",
language = "English",
volume = "512",
pages = "223--230",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "2-3",

}

TY - JOUR

T1 - Differential effect of prostaglandins E1 and E2 on lipopolysaccharide-induced adhesion molecule expression on human monocytes

AU - Takahashi, Hideo K.

AU - Iwagaki, Hiromi

AU - Tamura, Ryuji

AU - Katsuno, Goutaro

AU - Xue, Dong

AU - Sugita, Sachi

AU - Mori, Shuji

AU - Yoshino, Tadashi

AU - Tanaka, Noriaki

AU - Nishibori, Masahiro

PY - 2005/4/11

Y1 - 2005/4/11

N2 - The effect of prostaglandins E1 and E2 on the 1 ng/ml lipopolysaccharide-induced expression of intercellular adhesion molecule (ICAM)-1, B7.1, B7.2, CD40 and CD40 ligand (CD40L) on monocytes was examined. Prostaglandin E1 suppressed B7.1 and CD40 expression, but prostaglandin E2 did not effect on any type of adhesion molecule expression. Both prostaglandins inhibited tumor necrosis factor (TNF)-α production and T-cell proliferation of lipopolysaccharide-treated human peripheral blood mononuclear cells (PBMC). Among prostaglandin E1 receptors (IP/EP1/EP2/EP3/EP4) agonists, ONO-1301, a prostanoid IP-receptor agonist, prevented B7.1 and CD40 expression. ONO-AE1-259-01 a prostanoid EP2-receptor agonist, ONO-AE1-329, a prostanoid EP4-receptor agonist, and ONO-1301 inhibited TNF-α production and T-cell proliferation. Moreover, anti-B7.1 and anti-CD40 Abs prevented lipopolysaccharide-induced TNF-α production and T-cell proliferation. Therefore, the effect of prostaglandin E1 on TNF-α production and T-cell proliferation might depend on the inhibition of B7.1 and CD40 expression, but that of prostaglandin E2 might be independent of adhesion molecules expression. In conclusion, the mechanism responsible for the effect of prostaglandin E1 on lipopolysaccharide-induced responses is distinct from that of prostaglandin E2.

AB - The effect of prostaglandins E1 and E2 on the 1 ng/ml lipopolysaccharide-induced expression of intercellular adhesion molecule (ICAM)-1, B7.1, B7.2, CD40 and CD40 ligand (CD40L) on monocytes was examined. Prostaglandin E1 suppressed B7.1 and CD40 expression, but prostaglandin E2 did not effect on any type of adhesion molecule expression. Both prostaglandins inhibited tumor necrosis factor (TNF)-α production and T-cell proliferation of lipopolysaccharide-treated human peripheral blood mononuclear cells (PBMC). Among prostaglandin E1 receptors (IP/EP1/EP2/EP3/EP4) agonists, ONO-1301, a prostanoid IP-receptor agonist, prevented B7.1 and CD40 expression. ONO-AE1-259-01 a prostanoid EP2-receptor agonist, ONO-AE1-329, a prostanoid EP4-receptor agonist, and ONO-1301 inhibited TNF-α production and T-cell proliferation. Moreover, anti-B7.1 and anti-CD40 Abs prevented lipopolysaccharide-induced TNF-α production and T-cell proliferation. Therefore, the effect of prostaglandin E1 on TNF-α production and T-cell proliferation might depend on the inhibition of B7.1 and CD40 expression, but that of prostaglandin E2 might be independent of adhesion molecules expression. In conclusion, the mechanism responsible for the effect of prostaglandin E1 on lipopolysaccharide-induced responses is distinct from that of prostaglandin E2.

KW - Adhesion molecule

KW - Monocyte

KW - Prostaglandin

UR - http://www.scopus.com/inward/record.url?scp=20244385959&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20244385959&partnerID=8YFLogxK

U2 - 10.1016/j.ejphar.2005.01.046

DO - 10.1016/j.ejphar.2005.01.046

M3 - Article

C2 - 15840408

AN - SCOPUS:20244385959

VL - 512

SP - 223

EP - 230

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 2-3

ER -