Differential distribution of insulin-like growth factor-1 and insulin-like growth factor binding proteins in experimental diabetic rat kidney

Nobuyuki Miyatake, Kenichi Shikata, Jun Wada, Hikaru Sugimoto, Shin Ichiro Takahashi, Hirofumi Makino

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11 Citations (Scopus)


Insulin-like growth factor-1 (IGF-1) is a peptide growth factor, and its activity is modulated by interaction with the family of IGF binding proteins (IGFBP-1 to 6). IGF-1 is detected in rat kidney and has metabolic and growth effects. To explore the possible involvement of IGFBPs in glomerular hypertrophy in streptozotocin (STZ)-induced diabetic rat, the immunolocalization of IGF-1 and IGFBPs were investigated. IGF-1 was gradually increased in the glomeruli of diabetic rats and correlated with glomerular hypertrophy. IGFBP-1 was transiently increased at 1 week after the STZ injection and declined to control level during the following period. In contrast, IGFBP-4 was increased in the diabetic glomeruli throughout the observation period. With insulin treatment, the levels of IGF-1, IGFBP-1 and 4 were normalized and glomerular hypertrophy was prevented. Initial glomerular hypertrophy of diabetic nephropathy is a related IGF-1 action, which may be modulated by IGFBP-1 and 4.

Original languageEnglish
Pages (from-to)317-323
Number of pages7
Issue number3
Publication statusPublished - 1999



  • Diabetic rat
  • Glomerular hypertrophy
  • Insulin-like growth factor binding proteins
  • Insulin-like growth factor-1
  • Streptozotocin

ASJC Scopus subject areas

  • Nephrology

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