Different strategies between Japan and other countries for the diagnosis and treatment of early-stage lung cancer

Shinichiro Miyoshi

Research output: Contribution to journalArticle

Abstract

Lung cancer screening has been determined to be efficacious in Japan, while in Western countries it is considered to be ineffective. As a result, the strategies employed for the diagnosis and treatment of early-stage lung cancer (ESLC) differ, with more ESLC cases detected in Japan. Furthermore, a clinicopathological methodology has been developed by Japanese investigators in which an intentional segmentectomy is strictly indicated for patients with clinical T1NOM0 peripheral non-small cell lung cancer (NSCLC) of 2 cm or less in diameter, and wedge resection is only performed for type A or B adenocarcinoma classified according to Noguchi. The outcome of both procedures is similar to that of a lobectomy. On the other hand, a randomized, controlled trial (RCT) performed in North America showed the superiority of lobectomy compared with limited resection for T1NOM0 NSCLC, in which such strict criteria were not employed. Recently, procedures to reduce the area of mediastinal lymph node dissection (MLND) have been attempted for ESLC in Japan, while Western countries consider MLND important even in ESLC. Thus a large-scale RCT has been conducted to determine the superiority of MLND over lymph node sampling.

Original languageEnglish
Pages (from-to)329-332
Number of pages4
JournalNippon Geka Gakkai zasshi
Volume109
Issue number6
Publication statusPublished - Nov 2008
Externally publishedYes

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Lung Neoplasms
Japan
Lymph Node Excision
Non-Small Cell Lung Carcinoma
Randomized Controlled Trials
Therapeutics
Segmental Mastectomy
North America
Early Detection of Cancer
Adenocarcinoma
Lymph Nodes
Research Personnel

ASJC Scopus subject areas

  • Medicine(all)

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Different strategies between Japan and other countries for the diagnosis and treatment of early-stage lung cancer. / Miyoshi, Shinichiro.

In: Nippon Geka Gakkai zasshi, Vol. 109, No. 6, 11.2008, p. 329-332.

Research output: Contribution to journalArticle

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