Different secretion patterns of two molecular forms of cardiac adrenomedullin in pressure- and volume-overloaded human heart failure

Toshio Nishikimi, Hiroshi Asakawa, Hiroshi Iida, Yasushi Matsushita, Ikuko Shibasaki, Kazuyoshi Tadokoro, Yosuke Mori, Hideaki Mori, Yoshihiko Mochizuki, Yoshitaka Okamura, Shinichiro Miyoshi, Kenji Kangawa, Hiroaki Matsuoka

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background In the final step of production of adrenomedullin (AM), an inactive intermediate form of glycine-extended AM (AM-glycine) is converted to the active mature form of adrenomedullin (AM-mature) by enzymatic amidation. Recent studies have revealed that AM-mature and AM-glycine circulate in human plasma. In this study, we investigated the differences of the concentrations of cardiac AM between pressure-overloaded (PO) heart failure (HF) and volume-overloaded (VO)-HF in humans. Methods and results We measured AM-mature and AM-glycine by immunoradiometric assays in pericardial fluid and plasma in 38 patients who underwent valve replacement surgery (PO-HF: aortic stenosis, n=14; VO-HF: aortic or mitral regurgitation, n=24). Stable coronary artery disease with normal left ventricular function served as the control (n=24). Plasma AM-mature (VO-HF: +59%, PO-HF: +65%, P

Original languageEnglish
Pages (from-to)321-327
Number of pages7
JournalJournal of Cardiac Failure
Volume10
Issue number4
DOIs
Publication statusPublished - Aug 2004
Externally publishedYes

Fingerprint

Adrenomedullin
Heart Failure
Pressure
Glycine
Immunoradiometric Assay
Cardiac Volume
Aortic Valve Insufficiency
Aortic Valve Stenosis
Mitral Valve Insufficiency
Left Ventricular Function
Coronary Artery Disease

Keywords

  • Adrenomedullin
  • Heart failure
  • Pericardial fluid
  • Plasma
  • Pressure overload
  • Valvular
  • Volume overload

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Different secretion patterns of two molecular forms of cardiac adrenomedullin in pressure- and volume-overloaded human heart failure. / Nishikimi, Toshio; Asakawa, Hiroshi; Iida, Hiroshi; Matsushita, Yasushi; Shibasaki, Ikuko; Tadokoro, Kazuyoshi; Mori, Yosuke; Mori, Hideaki; Mochizuki, Yoshihiko; Okamura, Yoshitaka; Miyoshi, Shinichiro; Kangawa, Kenji; Matsuoka, Hiroaki.

In: Journal of Cardiac Failure, Vol. 10, No. 4, 08.2004, p. 321-327.

Research output: Contribution to journalArticle

Nishikimi, T, Asakawa, H, Iida, H, Matsushita, Y, Shibasaki, I, Tadokoro, K, Mori, Y, Mori, H, Mochizuki, Y, Okamura, Y, Miyoshi, S, Kangawa, K & Matsuoka, H 2004, 'Different secretion patterns of two molecular forms of cardiac adrenomedullin in pressure- and volume-overloaded human heart failure', Journal of Cardiac Failure, vol. 10, no. 4, pp. 321-327. https://doi.org/10.1016/j.cardfail.2003.12.002
Nishikimi, Toshio ; Asakawa, Hiroshi ; Iida, Hiroshi ; Matsushita, Yasushi ; Shibasaki, Ikuko ; Tadokoro, Kazuyoshi ; Mori, Yosuke ; Mori, Hideaki ; Mochizuki, Yoshihiko ; Okamura, Yoshitaka ; Miyoshi, Shinichiro ; Kangawa, Kenji ; Matsuoka, Hiroaki. / Different secretion patterns of two molecular forms of cardiac adrenomedullin in pressure- and volume-overloaded human heart failure. In: Journal of Cardiac Failure. 2004 ; Vol. 10, No. 4. pp. 321-327.
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