Different roles of histamine and leukotriene C4 in the airways between patients with atopic and nonatopic asthma

Fumihiro Mitsunobu, Takashi Mifune, Yasuhiro Hosaki, Kozo Ashida, Satoshi Yokota, Hirofumi Tsugeno, Yoshiro Tanizaki

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The release of histamine and leukotriene C4 (LTC4) from bronchoalveolar lavage (BAL) cells and peripheral blood stimulated with Ca ionophore A23187 was compared between atopic and nonatopic asthma. The proportion of basophilic cells in BAL fluid was significantly higher in atopic than in nonatopic asthma (p <0.01); however, no significant differences were present in the other BAL cells between the two asthma types. The concentration of histamine in BAL fluid was significantly higher in younger patients (20-59 years) with atopic than in nonatopic asthma (p <0.01). In contrast, the concentration of LTC4 was significantly higher in nonatopic than in younger patients with atopic asthma (p <0.01). The release of histamine from BAL cells (p <0.001) and peripheral blood (p <0.01) was significantly larger in younger patients with atopic than in nonatopic asthma. The generation of LTC4 by BAL cells was significantly larger in nonatopic than in younger (p <0.01) and older patients with atopic asthma (60+ years) (p <0.05). These results suggest that both histamine and LTC4 participate in the onset mechanism of atopic asthma, and only LTC4 participates in that of nonatopic asthma.

Original languageEnglish
Pages (from-to)367-372
Number of pages6
JournalJournal of Asthma
Volume35
Issue number4
Publication statusPublished - 1998

Fingerprint

Leukotriene C4
Histamine
Asthma
Bronchoalveolar Lavage
Histamine Release
Bronchoalveolar Lavage Fluid
Ionophores
Calcimycin
Blood Cells

Keywords

  • Bronchoalveolar lavage
  • Histamine
  • Leukotriene C

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Different roles of histamine and leukotriene C4 in the airways between patients with atopic and nonatopic asthma. / Mitsunobu, Fumihiro; Mifune, Takashi; Hosaki, Yasuhiro; Ashida, Kozo; Yokota, Satoshi; Tsugeno, Hirofumi; Tanizaki, Yoshiro.

In: Journal of Asthma, Vol. 35, No. 4, 1998, p. 367-372.

Research output: Contribution to journalArticle

Mitsunobu, Fumihiro ; Mifune, Takashi ; Hosaki, Yasuhiro ; Ashida, Kozo ; Yokota, Satoshi ; Tsugeno, Hirofumi ; Tanizaki, Yoshiro. / Different roles of histamine and leukotriene C4 in the airways between patients with atopic and nonatopic asthma. In: Journal of Asthma. 1998 ; Vol. 35, No. 4. pp. 367-372.
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