Different profiles of circulating angiogenic factors and adipocytokines between early- and late-onset pre-eclampsia

Hisashi Masuyama, T. Segawa, Y. Sumida, A. Masumoto, S. Inoue, Y. Akahori, Y. Hiramatsu

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Abstract

Objective Circulating angiogenic factors have been shown to be important in the pathophysiology of pre-eclampsia. Blood levels of adipocytokines differ in pre-eclampsia relative to controls and may also play an important role in disease pathogenesis. Differences in the circulating levels of these molecules were compared between matched normotensive controls and women with pre-eclampsia with onset before or at/after 32 weeks, and according to whether the women were of normal weight (18.5 <body mass index <25) or overweight. Design A cross-sectional study of 110 pregnant Japanese women who visited the Department of Obstetrics and Gynecology, Okayama University Hospital, Okayama, Japan. Setting Tertiary referral centre serving 2000 births. Methods Serum concentrations of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), soluble endoglin (sEng), adiponectin and leptin were measured in women with pre-eclampsia and in normotensive controls matched for age, gestational week, parity and body mass index. Main outcome measures Serum levels of sFlt-1, PlGF, the sFlt-1/PlGF ratio, sEng, adiponectin and leptin. Results The sFlt-1/PlGF ratio in early-onset pre-eclampsia was significantly higher than that in late-onset pre-eclampsia (112.0 ± 30.2 versus 45.4 ± 43.8, P = 0.037). There was a significant elevation of leptin in both subtypes relative to controls (early: 58.6 ± 18.3 ng/ml versus 26.0 ± 6.7 ng/ml, P = 0.001; late: 39.5 ± 9.2 ng/ml versus 22.0 ± 4.3 ng/ml, P = 0.005), but adiponectin was increased only in late-onset pre-eclampsia (36.5 ± 13.4 ̄g/ml versus 12.0 ± 4.3 ̄g/ml, P = 0.003). Significant differences in angiogenic factors and adiponectin were found between normal and overweight women only in late-onset pre-eclampsia. Conclusions These data suggest that there are different profiles of angiogenic factors and adipocytokines between women who develop early- and late-onset pre-eclampsia.

Original languageEnglish
Pages (from-to)314-320
Number of pages7
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume117
Issue number3
DOIs
Publication statusPublished - Feb 2010

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Adipokines
Angiogenesis Inducing Agents
Pre-Eclampsia
Vascular Endothelial Growth Factor Receptor-1
Adiponectin
Intercellular Signaling Peptides and Proteins
Leptin
Body Mass Index
Hospital Obstetrics and Gynecology Department
Parity
Serum
Gynecology
Tertiary Care Centers
Gestational Age
Pregnant Women
Japan
Cross-Sectional Studies
Outcome Assessment (Health Care)
Parturition
Weights and Measures

Keywords

  • Adipocytokines
  • Angiogenic factor
  • Obesity
  • Pre-eclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Different profiles of circulating angiogenic factors and adipocytokines between early- and late-onset pre-eclampsia. / Masuyama, Hisashi; Segawa, T.; Sumida, Y.; Masumoto, A.; Inoue, S.; Akahori, Y.; Hiramatsu, Y.

In: BJOG: An International Journal of Obstetrics and Gynaecology, Vol. 117, No. 3, 02.2010, p. 314-320.

Research output: Contribution to journalArticle

Masuyama, Hisashi ; Segawa, T. ; Sumida, Y. ; Masumoto, A. ; Inoue, S. ; Akahori, Y. ; Hiramatsu, Y. / Different profiles of circulating angiogenic factors and adipocytokines between early- and late-onset pre-eclampsia. In: BJOG: An International Journal of Obstetrics and Gynaecology. 2010 ; Vol. 117, No. 3. pp. 314-320.
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