Different histopathological types of orbital lymphoma 16 years after systemic follicular lymphoma: immunohistochemical and immunogenetic analyses of two cases.

Toshihiko Matsuo, Kouichi Ichimura, Katsuji Shinagawa, Tadashi Yoshino

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The purpose of this study is to show that the histopathological type of an orbital lymphoma can differ from the systemic follicular lymphoma that precedes it. A 44-year-old man (Patient #1) and a 50-year-old man (Patient #2) presented with generalized lymphadenopathy due to grade 1 follicular lymphoma proven on lymph node biopsy. Patient #1 was followed without treatment for 16 years when he developed a right orbital mass. Patient #2 underwent several courses of combination chemotherapy as well as radiation but relapsed. The second biopsy of the lymph node nine years later showed the same histopathological type of follicular lymphoma. He developed an orbital mass on the right side 16 years after the initial presentation. In Patient #1, excisional biopsy of the orbital masses showed extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In Patient #2, biopsy revealed the orbital mass to be T-cell/histiocyte-rich diffuse large B-cell lymphoma. In Patient #1, when comparing the original lymph node biopsy to the orbital biopsy obtained years later, no evidence for clonality was noted by polymerase chain reaction. In Patient #2, the amplification by polymerase chain reaction of the immunoglobulin heavy chain gene rearrangement in the lymph node lesion and the orbital lesion gave rise to a single discrete band with the same DNA sequence except for five nucleotide changes, indicating the same clonality in the presence of genomic changes. In conclusion, orbital lymphomas can occur as a second lymphoma with a different histopathological type in the long-term follow-up of systemic lymphomas. The original and subsequent lymphomatous lesions may or may not share neoplastic cell clonality and all genomics.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalJournal of clinical and experimental hematopathology : JCEH
Volume48
Issue number1
DOIs
Publication statusPublished - Apr 2008

Fingerprint

Immunogenetics
Follicular Lymphoma
Marginal Zone B-Cell Lymphoma
Biopsy
Lymph Nodes
Lymphoma
Immunoglobulin Heavy Chain Genes
Polymerase Chain Reaction
Histiocytes
Lymphoma, Large B-Cell, Diffuse
Orbital lymphoma
Gene Rearrangement
Genomics
Combination Drug Therapy
Nucleotides
Radiation
T-Lymphocytes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{08b4338c308646929227656560c23862,
title = "Different histopathological types of orbital lymphoma 16 years after systemic follicular lymphoma: immunohistochemical and immunogenetic analyses of two cases.",
abstract = "The purpose of this study is to show that the histopathological type of an orbital lymphoma can differ from the systemic follicular lymphoma that precedes it. A 44-year-old man (Patient #1) and a 50-year-old man (Patient #2) presented with generalized lymphadenopathy due to grade 1 follicular lymphoma proven on lymph node biopsy. Patient #1 was followed without treatment for 16 years when he developed a right orbital mass. Patient #2 underwent several courses of combination chemotherapy as well as radiation but relapsed. The second biopsy of the lymph node nine years later showed the same histopathological type of follicular lymphoma. He developed an orbital mass on the right side 16 years after the initial presentation. In Patient #1, excisional biopsy of the orbital masses showed extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In Patient #2, biopsy revealed the orbital mass to be T-cell/histiocyte-rich diffuse large B-cell lymphoma. In Patient #1, when comparing the original lymph node biopsy to the orbital biopsy obtained years later, no evidence for clonality was noted by polymerase chain reaction. In Patient #2, the amplification by polymerase chain reaction of the immunoglobulin heavy chain gene rearrangement in the lymph node lesion and the orbital lesion gave rise to a single discrete band with the same DNA sequence except for five nucleotide changes, indicating the same clonality in the presence of genomic changes. In conclusion, orbital lymphomas can occur as a second lymphoma with a different histopathological type in the long-term follow-up of systemic lymphomas. The original and subsequent lymphomatous lesions may or may not share neoplastic cell clonality and all genomics.",
author = "Toshihiko Matsuo and Kouichi Ichimura and Katsuji Shinagawa and Tadashi Yoshino",
year = "2008",
month = "4",
doi = "10.3960/jslrt.48.17",
language = "English",
volume = "48",
pages = "17--24",
journal = "Journal of clinical and experimental hematopathology : JCEH",
issn = "1346-4280",
publisher = "Nihon Rinpa Monaikei Gakkai",
number = "1",

}

TY - JOUR

T1 - Different histopathological types of orbital lymphoma 16 years after systemic follicular lymphoma

T2 - immunohistochemical and immunogenetic analyses of two cases.

AU - Matsuo, Toshihiko

AU - Ichimura, Kouichi

AU - Shinagawa, Katsuji

AU - Yoshino, Tadashi

PY - 2008/4

Y1 - 2008/4

N2 - The purpose of this study is to show that the histopathological type of an orbital lymphoma can differ from the systemic follicular lymphoma that precedes it. A 44-year-old man (Patient #1) and a 50-year-old man (Patient #2) presented with generalized lymphadenopathy due to grade 1 follicular lymphoma proven on lymph node biopsy. Patient #1 was followed without treatment for 16 years when he developed a right orbital mass. Patient #2 underwent several courses of combination chemotherapy as well as radiation but relapsed. The second biopsy of the lymph node nine years later showed the same histopathological type of follicular lymphoma. He developed an orbital mass on the right side 16 years after the initial presentation. In Patient #1, excisional biopsy of the orbital masses showed extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In Patient #2, biopsy revealed the orbital mass to be T-cell/histiocyte-rich diffuse large B-cell lymphoma. In Patient #1, when comparing the original lymph node biopsy to the orbital biopsy obtained years later, no evidence for clonality was noted by polymerase chain reaction. In Patient #2, the amplification by polymerase chain reaction of the immunoglobulin heavy chain gene rearrangement in the lymph node lesion and the orbital lesion gave rise to a single discrete band with the same DNA sequence except for five nucleotide changes, indicating the same clonality in the presence of genomic changes. In conclusion, orbital lymphomas can occur as a second lymphoma with a different histopathological type in the long-term follow-up of systemic lymphomas. The original and subsequent lymphomatous lesions may or may not share neoplastic cell clonality and all genomics.

AB - The purpose of this study is to show that the histopathological type of an orbital lymphoma can differ from the systemic follicular lymphoma that precedes it. A 44-year-old man (Patient #1) and a 50-year-old man (Patient #2) presented with generalized lymphadenopathy due to grade 1 follicular lymphoma proven on lymph node biopsy. Patient #1 was followed without treatment for 16 years when he developed a right orbital mass. Patient #2 underwent several courses of combination chemotherapy as well as radiation but relapsed. The second biopsy of the lymph node nine years later showed the same histopathological type of follicular lymphoma. He developed an orbital mass on the right side 16 years after the initial presentation. In Patient #1, excisional biopsy of the orbital masses showed extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In Patient #2, biopsy revealed the orbital mass to be T-cell/histiocyte-rich diffuse large B-cell lymphoma. In Patient #1, when comparing the original lymph node biopsy to the orbital biopsy obtained years later, no evidence for clonality was noted by polymerase chain reaction. In Patient #2, the amplification by polymerase chain reaction of the immunoglobulin heavy chain gene rearrangement in the lymph node lesion and the orbital lesion gave rise to a single discrete band with the same DNA sequence except for five nucleotide changes, indicating the same clonality in the presence of genomic changes. In conclusion, orbital lymphomas can occur as a second lymphoma with a different histopathological type in the long-term follow-up of systemic lymphomas. The original and subsequent lymphomatous lesions may or may not share neoplastic cell clonality and all genomics.

UR - http://www.scopus.com/inward/record.url?scp=49649091333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49649091333&partnerID=8YFLogxK

U2 - 10.3960/jslrt.48.17

DO - 10.3960/jslrt.48.17

M3 - Article

C2 - 18434689

AN - SCOPUS:49649091333

VL - 48

SP - 17

EP - 24

JO - Journal of clinical and experimental hematopathology : JCEH

JF - Journal of clinical and experimental hematopathology : JCEH

SN - 1346-4280

IS - 1

ER -