Different Expression Patterns of beta-Defensins in Human Squamous Cell Carcinomas

Tomohito Yoshimoto, Tomoichiro Yamaai, Nobuyoshi Mizukawa, Koichi Sawaki, Makoto Nakano, Eiki Yamachika, Toshio Sugahara

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29 Citations (Scopus)

Abstract

The expression of human β-defensin genes in oral squamous cell carcinomas(SCCs) was demonstrated by in situ hybridization. The expression of HBD-2 was observed not only in the inflamed lesions with bacterial infection but also in the non-inflamed carcinomas themselves (evident in 15 out of 20 carcinomas). However, HBD-3 expression was found in only 4 out of 20 SCCs. In the normal oral epithelia, the expression of HBD-2 and HBD-3 was only detected in the areas adjacent to the SCCs. These results suggest that HBD-2 might play a role in SCCs, which is different from the native defensive role of these proteins. HBD-2 may lead to the death of normal keratinocytes adjacent to the SCCs, which might, in turn, indirectly assist in the multiplication of tumor cells.

Original languageEnglish
Pages (from-to)4629-4633
Number of pages5
JournalAnticancer research
Volume23
Issue number6 C
Publication statusPublished - Nov 1 2003

Keywords

  • Defensin
  • Oral tumor
  • Squamous cell carcinomas
  • β defensin-2
  • β defensin-3

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Yoshimoto, T., Yamaai, T., Mizukawa, N., Sawaki, K., Nakano, M., Yamachika, E., & Sugahara, T. (2003). Different Expression Patterns of beta-Defensins in Human Squamous Cell Carcinomas. Anticancer research, 23(6 C), 4629-4633.