Different expression of low density lipoprotein receptor and ApoE between young adult and old rat brains after ischemia

Takeshi Hayashi, Hiroshi Kamada, Guang Jin, Kentaro Deguchi, Shoko Nagotani, Yoshihide Sehara, Hanzhe Zhang, Isao Nagano, Mikio Shoji, Koji Abe

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: Reduction of brain plasticity underlies the poor outcome of aged stroke patients. The molecular mechanism of plasticity reduction by aging is uncertain, but disturbed lipid metabolism may be implicated. Methods: We investigated the expression of low density lipoprotein receptors (LDL-R) and apolipoprotein E (ApoE), both of which play active roles in lipid metabolism in young adult and old rat brains after ischemia. Results: LDL-R, trivially expressed in the sham-operated brain neurons, was increased from day 1 and became prominent at days 7 and 21 at the peri-ischemic cortex. The magnitude was smaller in the old than in the young adult rats. ApoE was increased in the astrocytes and neurons of the peri-ischemic cortex at day 1, which became further pronounced in the neurons but not in the astrocytes at days 7 and 21. ApoE expression was again less prominent in the old animals at days 7 and 21. Discussion: As ApoE-containing lipoprotein is recruited via LDL-R, the present results suggest that old brains had less capability to induce LDL-R, which resulted in impaired recruitment of lipoprotein after the ischemic injury. Impaired lipid recruitment causes disturbance of synaptogenesis and thus brain plasticity reduction. This molecular mechanism may result in poor functional recovery of aged stroke patients.

Original languageEnglish
Pages (from-to)822-825
Number of pages4
JournalNeurological Research
Volume28
Issue number8
DOIs
Publication statusPublished - Dec 2006

Keywords

  • Age
  • Ischemia
  • Lipid
  • Plasticity

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Hayashi, T., Kamada, H., Jin, G., Deguchi, K., Nagotani, S., Sehara, Y., Zhang, H., Nagano, I., Shoji, M., & Abe, K. (2006). Different expression of low density lipoprotein receptor and ApoE between young adult and old rat brains after ischemia. Neurological Research, 28(8), 822-825. https://doi.org/10.1179/016164105X40002