Different dicer-like protein components required for intracellular and systemic antiviral silencing in arabidopsis thaliana

Andika Ida Bagus, Kazuyuki Maruyama, Liying Sun, Hideki Kondo, Tetsuo Tamada, Nobuhiro Suzuki

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Eukaryotes employ RNA silencing as an innate defense system against invading viruses. Dicer proteins play the most crucial role in initiating this antiviral pathway as they recognize and process incoming viral nucleic acids into small interfering RNAs. Generally, 2 successive infection stages constitute viral infection in plants. First, the virus multiplies in initially infected cells or organs after viral transmission and then the virus subsequently spreads systemically through the vasculature to distal plant tissues or organs. Thus, antiviral silencing in plants must cope with both local and systemic invasion of viruses. In a recent study using 2 sets of different experiments, we clearly demonstrated the differential requirement for Dicer-like 4 (DCL4) and DCL2 proteins in the inhibition of intracellular and systemic infection by potato virus X in Arabidopsis thaliana. Taken together with the results of other studies, here we further discuss the functional specificity of DCL proteins in the antiviral silencing pathway.

Original languageEnglish
JournalPlant Signaling and Behavior
Volume10
Issue number8
DOIs
Publication statusPublished - 2015

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Arabidopsis thaliana
viruses
proteins
antiviral proteins
Potato virus X
plant viruses
plant organs
small interfering RNA
RNA interference
infection
nucleic acids
eukaryotic cells
plant tissues
cells

Keywords

  • Antiviral defense
  • Arabidopsis thaliana
  • Dicer-like protein
  • Potato virus X
  • RNA silencing

ASJC Scopus subject areas

  • Plant Science

Cite this

Different dicer-like protein components required for intracellular and systemic antiviral silencing in arabidopsis thaliana. / Ida Bagus, Andika; Maruyama, Kazuyuki; Sun, Liying; Kondo, Hideki; Tamada, Tetsuo; Suzuki, Nobuhiro.

In: Plant Signaling and Behavior, Vol. 10, No. 8, 2015.

Research output: Contribution to journalArticle

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AU - Tamada, Tetsuo

AU - Suzuki, Nobuhiro

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