Different associations of plasma biomarkers in alzheimer’s disease, mild cognitive impairment, vascular dementia, and ischemic stroke

Jingwei Shang, Toru Yamashita, Yusuke Fukui, Dongjing Song, Xianghong Li, Yun Zhai, Yumiko Nakano, Ryuta Morihara, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background and Purpose Cognitive and cerebrovascular diseases are common in the elderly, but differences in the plasma levels and associations of plasma biomarkers in these diseases remain elusive. Methods The present study investigated differences in plasma fatty acids [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)], adiponectin, reptin, plasma markers of inflammation [high-sensitivity C-reactive protein (hsCRP) and serum amyloid A (serum AA)], and plasma lipids [high-density lipoprotein and low-density lipoprotein (LDL)] in patients with Alzheimer’s disease (AD) (n=266), mild cognitive impairment (MCI) (n=44), vascular dementia (VaD) (n=33), and ischemic stroke (IS) (n=200) in comparison to normal controls (n=130). Results The serological data showed that lower EPA and DHA levels and higher reptin and LDL levels were associated with AD and IS, the reptin/adiponectin ratio was strongly associated with IS, the hsCRP level was more strongly associated with VaD and IS, and the serum AA level was associated with all three cognitive diseases and IS. Conclusions This is the first report of differences in the expression levels of plasma biomarkers and peripheral arterial tonometry among AD, MCI, VaD, and IS patients and normal controls. These different associations indicate that diverse pathological mechanisms underlie these diseases.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalJournal of Clinical Neurology (Korea)
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Vascular Dementia
Alzheimer Disease
Biomarkers
Stroke
Serum Amyloid A Protein
Eicosapentaenoic Acid
Docosahexaenoic Acids
Adiponectin
LDL Lipoproteins
C-Reactive Protein
Cerebrovascular Disorders
Manometry
HDL Lipoproteins
Cognitive Dysfunction
Fatty Acids
Inflammation
Lipids

Keywords

  • Alzheimer’s disease
  • Ischemic stroke
  • Mild cognitive impairment
  • Plasma biomarker
  • Vascular dementia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Different associations of plasma biomarkers in alzheimer’s disease, mild cognitive impairment, vascular dementia, and ischemic stroke. / Shang, Jingwei; Yamashita, Toru; Fukui, Yusuke; Song, Dongjing; Li, Xianghong; Zhai, Yun; Nakano, Yumiko; Morihara, Ryuta; Hishikawa, Nozomi; Ohta, Yasuyuki; Abe, Koji.

In: Journal of Clinical Neurology (Korea), Vol. 14, No. 1, 01.01.2018, p. 29-34.

Research output: Contribution to journalArticle

@article{5f40b94ab1274eaaa2fb9716bba40245,
title = "Different associations of plasma biomarkers in alzheimer’s disease, mild cognitive impairment, vascular dementia, and ischemic stroke",
abstract = "Background and Purpose Cognitive and cerebrovascular diseases are common in the elderly, but differences in the plasma levels and associations of plasma biomarkers in these diseases remain elusive. Methods The present study investigated differences in plasma fatty acids [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)], adiponectin, reptin, plasma markers of inflammation [high-sensitivity C-reactive protein (hsCRP) and serum amyloid A (serum AA)], and plasma lipids [high-density lipoprotein and low-density lipoprotein (LDL)] in patients with Alzheimer’s disease (AD) (n=266), mild cognitive impairment (MCI) (n=44), vascular dementia (VaD) (n=33), and ischemic stroke (IS) (n=200) in comparison to normal controls (n=130). Results The serological data showed that lower EPA and DHA levels and higher reptin and LDL levels were associated with AD and IS, the reptin/adiponectin ratio was strongly associated with IS, the hsCRP level was more strongly associated with VaD and IS, and the serum AA level was associated with all three cognitive diseases and IS. Conclusions This is the first report of differences in the expression levels of plasma biomarkers and peripheral arterial tonometry among AD, MCI, VaD, and IS patients and normal controls. These different associations indicate that diverse pathological mechanisms underlie these diseases.",
keywords = "Alzheimer’s disease, Ischemic stroke, Mild cognitive impairment, Plasma biomarker, Vascular dementia",
author = "Jingwei Shang and Toru Yamashita and Yusuke Fukui and Dongjing Song and Xianghong Li and Yun Zhai and Yumiko Nakano and Ryuta Morihara and Nozomi Hishikawa and Yasuyuki Ohta and Koji Abe",
year = "2018",
month = "1",
day = "1",
doi = "10.3988/jcn.2018.14.1.29",
language = "English",
volume = "14",
pages = "29--34",
journal = "Journal of Clinical Neurology (Korea)",
issn = "1738-6586",
publisher = "Korean Neurological Association",
number = "1",

}

TY - JOUR

T1 - Different associations of plasma biomarkers in alzheimer’s disease, mild cognitive impairment, vascular dementia, and ischemic stroke

AU - Shang, Jingwei

AU - Yamashita, Toru

AU - Fukui, Yusuke

AU - Song, Dongjing

AU - Li, Xianghong

AU - Zhai, Yun

AU - Nakano, Yumiko

AU - Morihara, Ryuta

AU - Hishikawa, Nozomi

AU - Ohta, Yasuyuki

AU - Abe, Koji

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background and Purpose Cognitive and cerebrovascular diseases are common in the elderly, but differences in the plasma levels and associations of plasma biomarkers in these diseases remain elusive. Methods The present study investigated differences in plasma fatty acids [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)], adiponectin, reptin, plasma markers of inflammation [high-sensitivity C-reactive protein (hsCRP) and serum amyloid A (serum AA)], and plasma lipids [high-density lipoprotein and low-density lipoprotein (LDL)] in patients with Alzheimer’s disease (AD) (n=266), mild cognitive impairment (MCI) (n=44), vascular dementia (VaD) (n=33), and ischemic stroke (IS) (n=200) in comparison to normal controls (n=130). Results The serological data showed that lower EPA and DHA levels and higher reptin and LDL levels were associated with AD and IS, the reptin/adiponectin ratio was strongly associated with IS, the hsCRP level was more strongly associated with VaD and IS, and the serum AA level was associated with all three cognitive diseases and IS. Conclusions This is the first report of differences in the expression levels of plasma biomarkers and peripheral arterial tonometry among AD, MCI, VaD, and IS patients and normal controls. These different associations indicate that diverse pathological mechanisms underlie these diseases.

AB - Background and Purpose Cognitive and cerebrovascular diseases are common in the elderly, but differences in the plasma levels and associations of plasma biomarkers in these diseases remain elusive. Methods The present study investigated differences in plasma fatty acids [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)], adiponectin, reptin, plasma markers of inflammation [high-sensitivity C-reactive protein (hsCRP) and serum amyloid A (serum AA)], and plasma lipids [high-density lipoprotein and low-density lipoprotein (LDL)] in patients with Alzheimer’s disease (AD) (n=266), mild cognitive impairment (MCI) (n=44), vascular dementia (VaD) (n=33), and ischemic stroke (IS) (n=200) in comparison to normal controls (n=130). Results The serological data showed that lower EPA and DHA levels and higher reptin and LDL levels were associated with AD and IS, the reptin/adiponectin ratio was strongly associated with IS, the hsCRP level was more strongly associated with VaD and IS, and the serum AA level was associated with all three cognitive diseases and IS. Conclusions This is the first report of differences in the expression levels of plasma biomarkers and peripheral arterial tonometry among AD, MCI, VaD, and IS patients and normal controls. These different associations indicate that diverse pathological mechanisms underlie these diseases.

KW - Alzheimer’s disease

KW - Ischemic stroke

KW - Mild cognitive impairment

KW - Plasma biomarker

KW - Vascular dementia

UR - http://www.scopus.com/inward/record.url?scp=85040692878&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040692878&partnerID=8YFLogxK

U2 - 10.3988/jcn.2018.14.1.29

DO - 10.3988/jcn.2018.14.1.29

M3 - Article

AN - SCOPUS:85040692878

VL - 14

SP - 29

EP - 34

JO - Journal of Clinical Neurology (Korea)

JF - Journal of Clinical Neurology (Korea)

SN - 1738-6586

IS - 1

ER -