Different angiogenic pathways in human cervical cancers

Keizo Tokumo, Junichi Kodama, Noriko Seki, Yoshie Nakanishi, Yasunari Miyagi, Shigehito Kamimura, Mitsuo Yoshinouchi, Hiroyuki Okuda, Takafumi Kudo

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Objective. The objective of this study is to clarify the association between the expression of two types angiogenic factors, vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD- ECGF)/thymidine phosphorylase (dThdPase) and clinicopathological features, including tumor angiogenesis, in cervical cancers. Methods. The expression of VEGF and PD-ECGF was evaluated by immunohistochemical staining of tumor specimens from 73 patients with stage Ib-IIb cervical cancer (51, squamous cell carcinoma; 19, adenocarcinoma; 3, adenosquamous carcinoma) who underwent radical hysterectomy. The microvessel density was assessed by immunostaining for factor VIII-related antigen in the most neovascularized area. Results. The microvessel density in adenocarcinomas was significantly higher than that in squamous cell carcinomas (P <0.01). The intensity of VEGF expression in adenocarcinomas was significantly stronger than that in squamous cell carcinomas (P <0.05). In contrast, the expression of PD-ECGF in squamous cell carcinomas was significantly higher than that in adenocarcinomas (P <0.0001) and adenosquamous carcinomas (P <0.01). There was an inverse relationship between VEGF expression and PD-ECGF expression among all patients studied (P <0.001). The microvessel density was significantly correlated with the intensity of VEGF expression (P <0.05). In contrast, there was no correlation between the microvessel density and the expression of PD-ECGF. Conclusions. The expression of VEGF appears to be involved in the promotion of angiogenesis in cervical cancers. Furthermore, we propose that angiogenic pathways may be different in different types of cervical cancers.

Original languageEnglish
Pages (from-to)38-44
Number of pages7
JournalGynecologic Oncology
Volume68
Issue number1
DOIs
Publication statusPublished - Jan 1998

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Thymidine Phosphorylase
Uterine Cervical Neoplasms
Vascular Endothelial Growth Factor A
Adenosquamous Carcinoma
Microvessels
Squamous Cell Carcinoma
Adenocarcinoma
Angiogenesis Inducing Agents
von Willebrand Factor
Hysterectomy
Neoplasms
Staining and Labeling

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

Tokumo, K., Kodama, J., Seki, N., Nakanishi, Y., Miyagi, Y., Kamimura, S., ... Kudo, T. (1998). Different angiogenic pathways in human cervical cancers. Gynecologic Oncology, 68(1), 38-44. https://doi.org/10.1006/gyno.1997.4876

Different angiogenic pathways in human cervical cancers. / Tokumo, Keizo; Kodama, Junichi; Seki, Noriko; Nakanishi, Yoshie; Miyagi, Yasunari; Kamimura, Shigehito; Yoshinouchi, Mitsuo; Okuda, Hiroyuki; Kudo, Takafumi.

In: Gynecologic Oncology, Vol. 68, No. 1, 01.1998, p. 38-44.

Research output: Contribution to journalArticle

Tokumo, K, Kodama, J, Seki, N, Nakanishi, Y, Miyagi, Y, Kamimura, S, Yoshinouchi, M, Okuda, H & Kudo, T 1998, 'Different angiogenic pathways in human cervical cancers', Gynecologic Oncology, vol. 68, no. 1, pp. 38-44. https://doi.org/10.1006/gyno.1997.4876
Tokumo K, Kodama J, Seki N, Nakanishi Y, Miyagi Y, Kamimura S et al. Different angiogenic pathways in human cervical cancers. Gynecologic Oncology. 1998 Jan;68(1):38-44. https://doi.org/10.1006/gyno.1997.4876
Tokumo, Keizo ; Kodama, Junichi ; Seki, Noriko ; Nakanishi, Yoshie ; Miyagi, Yasunari ; Kamimura, Shigehito ; Yoshinouchi, Mitsuo ; Okuda, Hiroyuki ; Kudo, Takafumi. / Different angiogenic pathways in human cervical cancers. In: Gynecologic Oncology. 1998 ; Vol. 68, No. 1. pp. 38-44.
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