Differences in body temperature variability between subjects with and without diabetes and predictive value for cardiovascular events

Eisuke Amiya, Masafumi Watanabe, Munenori Takata, Shogo Watanabe, Atsuko Ozeki, Aya Watanabe, Shuichi Kawarasaki, Tomoko Nakao, Yumiko Hosoya, Kazuko Omori, Koji Maemura, Yasunobu Hirata, Ryozo Nagai, Issei Komuro

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Differences in regulating factors and the clinical implications of body temperature variability (BTV) between subjects with and without diabetes have not been clarified to date. Methods and Results: In 66 subjects with ischemic heart disease (33 with diabetes and 33 without diabetes), BTV, the difference between the highest and lowest temperature measurements, and body temperature standard deviation (BT SD) were measured from axillary body temperature (ABT) records of 3 consecutive days and followed for 16.4±8.4 months. In subjects without diabetes BTV and BT SD were closely associated with endothelial function as evaluated on flow-mediated dilation (BTV, R=0.33, P=0.026; BT SD, R=0.41, P=0.029), whereas there was a poor association in subjects with diabetes. In the absence of an interrelationship between vascular function and thermoregulation, the contribution of inflammation to BTV was increased in subjects with diabetes (BTV, 0.59±0.21°C for C-reactive protein [CRP] 0.08 mg/dl, P=0.014). Event-free survival analysis showed that in subjects with diabetes higher BT SD was associated with shorter event-free survival (log-rank P=0.012), but this relationship was not found in subjects without diabetes. Conclusions: In subjects with diabetes, the interrelationship between thermoregulation and vascular function was disrupted and the effect of inflammation on thermoregulation was enhanced, so that BTV had a sufficient predictive value for cardiovascular events in diabetic subjects. (Circ J 2013; 77: 1844 - 1853).

Original languageEnglish
Pages (from-to)1844-1853
Number of pages10
JournalCirculation Journal
Volume77
Issue number7
DOIs
Publication statusPublished - 2013
Externally publishedYes

Fingerprint

Body Temperature
Body Temperature Regulation
Disease-Free Survival
Blood Vessels
Inflammation
Survival Analysis
C-Reactive Protein
Myocardial Ischemia
Dilatation

Keywords

  • Body temperature variability
  • Diabetes
  • Endothelial function
  • Ischemic heart disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Differences in body temperature variability between subjects with and without diabetes and predictive value for cardiovascular events. / Amiya, Eisuke; Watanabe, Masafumi; Takata, Munenori; Watanabe, Shogo; Ozeki, Atsuko; Watanabe, Aya; Kawarasaki, Shuichi; Nakao, Tomoko; Hosoya, Yumiko; Omori, Kazuko; Maemura, Koji; Hirata, Yasunobu; Nagai, Ryozo; Komuro, Issei.

In: Circulation Journal, Vol. 77, No. 7, 2013, p. 1844-1853.

Research output: Contribution to journalArticle

Amiya, E, Watanabe, M, Takata, M, Watanabe, S, Ozeki, A, Watanabe, A, Kawarasaki, S, Nakao, T, Hosoya, Y, Omori, K, Maemura, K, Hirata, Y, Nagai, R & Komuro, I 2013, 'Differences in body temperature variability between subjects with and without diabetes and predictive value for cardiovascular events', Circulation Journal, vol. 77, no. 7, pp. 1844-1853. https://doi.org/10.1253/circj.CJ-13-0012
Amiya, Eisuke ; Watanabe, Masafumi ; Takata, Munenori ; Watanabe, Shogo ; Ozeki, Atsuko ; Watanabe, Aya ; Kawarasaki, Shuichi ; Nakao, Tomoko ; Hosoya, Yumiko ; Omori, Kazuko ; Maemura, Koji ; Hirata, Yasunobu ; Nagai, Ryozo ; Komuro, Issei. / Differences in body temperature variability between subjects with and without diabetes and predictive value for cardiovascular events. In: Circulation Journal. 2013 ; Vol. 77, No. 7. pp. 1844-1853.
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abstract = "Background: Differences in regulating factors and the clinical implications of body temperature variability (BTV) between subjects with and without diabetes have not been clarified to date. Methods and Results: In 66 subjects with ischemic heart disease (33 with diabetes and 33 without diabetes), BTV, the difference between the highest and lowest temperature measurements, and body temperature standard deviation (BT SD) were measured from axillary body temperature (ABT) records of 3 consecutive days and followed for 16.4±8.4 months. In subjects without diabetes BTV and BT SD were closely associated with endothelial function as evaluated on flow-mediated dilation (BTV, R=0.33, P=0.026; BT SD, R=0.41, P=0.029), whereas there was a poor association in subjects with diabetes. In the absence of an interrelationship between vascular function and thermoregulation, the contribution of inflammation to BTV was increased in subjects with diabetes (BTV, 0.59±0.21°C for C-reactive protein [CRP] 0.08 mg/dl, P=0.014). Event-free survival analysis showed that in subjects with diabetes higher BT SD was associated with shorter event-free survival (log-rank P=0.012), but this relationship was not found in subjects without diabetes. Conclusions: In subjects with diabetes, the interrelationship between thermoregulation and vascular function was disrupted and the effect of inflammation on thermoregulation was enhanced, so that BTV had a sufficient predictive value for cardiovascular events in diabetic subjects. (Circ J 2013; 77: 1844 - 1853).",
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AU - Amiya, Eisuke

AU - Watanabe, Masafumi

AU - Takata, Munenori

AU - Watanabe, Shogo

AU - Ozeki, Atsuko

AU - Watanabe, Aya

AU - Kawarasaki, Shuichi

AU - Nakao, Tomoko

AU - Hosoya, Yumiko

AU - Omori, Kazuko

AU - Maemura, Koji

AU - Hirata, Yasunobu

AU - Nagai, Ryozo

AU - Komuro, Issei

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N2 - Background: Differences in regulating factors and the clinical implications of body temperature variability (BTV) between subjects with and without diabetes have not been clarified to date. Methods and Results: In 66 subjects with ischemic heart disease (33 with diabetes and 33 without diabetes), BTV, the difference between the highest and lowest temperature measurements, and body temperature standard deviation (BT SD) were measured from axillary body temperature (ABT) records of 3 consecutive days and followed for 16.4±8.4 months. In subjects without diabetes BTV and BT SD were closely associated with endothelial function as evaluated on flow-mediated dilation (BTV, R=0.33, P=0.026; BT SD, R=0.41, P=0.029), whereas there was a poor association in subjects with diabetes. In the absence of an interrelationship between vascular function and thermoregulation, the contribution of inflammation to BTV was increased in subjects with diabetes (BTV, 0.59±0.21°C for C-reactive protein [CRP] 0.08 mg/dl, P=0.014). Event-free survival analysis showed that in subjects with diabetes higher BT SD was associated with shorter event-free survival (log-rank P=0.012), but this relationship was not found in subjects without diabetes. Conclusions: In subjects with diabetes, the interrelationship between thermoregulation and vascular function was disrupted and the effect of inflammation on thermoregulation was enhanced, so that BTV had a sufficient predictive value for cardiovascular events in diabetic subjects. (Circ J 2013; 77: 1844 - 1853).

AB - Background: Differences in regulating factors and the clinical implications of body temperature variability (BTV) between subjects with and without diabetes have not been clarified to date. Methods and Results: In 66 subjects with ischemic heart disease (33 with diabetes and 33 without diabetes), BTV, the difference between the highest and lowest temperature measurements, and body temperature standard deviation (BT SD) were measured from axillary body temperature (ABT) records of 3 consecutive days and followed for 16.4±8.4 months. In subjects without diabetes BTV and BT SD were closely associated with endothelial function as evaluated on flow-mediated dilation (BTV, R=0.33, P=0.026; BT SD, R=0.41, P=0.029), whereas there was a poor association in subjects with diabetes. In the absence of an interrelationship between vascular function and thermoregulation, the contribution of inflammation to BTV was increased in subjects with diabetes (BTV, 0.59±0.21°C for C-reactive protein [CRP] 0.08 mg/dl, P=0.014). Event-free survival analysis showed that in subjects with diabetes higher BT SD was associated with shorter event-free survival (log-rank P=0.012), but this relationship was not found in subjects without diabetes. Conclusions: In subjects with diabetes, the interrelationship between thermoregulation and vascular function was disrupted and the effect of inflammation on thermoregulation was enhanced, so that BTV had a sufficient predictive value for cardiovascular events in diabetic subjects. (Circ J 2013; 77: 1844 - 1853).

KW - Body temperature variability

KW - Diabetes

KW - Endothelial function

KW - Ischemic heart disease

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