Difference in tolerance development to hypothermia and pentobarbital-induced sleep prolongating effect of 11-hydroxy-Δ8-tetrahydrocannabinol and 11-oxo-Δ8-tetrahydrocannabinol in mice

Kazuhito Watanabe, Shizuo Narimatsu, Ikuo Yamamoto, Hidetoshi Yoshimura

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Daily administration (5 mg/kg i.v.) of 11-hydroxy-Δ8-tetrahydrocannabinol or 11-oxo-Δ8-tetrahydrocannabinol as well Δ8-tetrahydrocannabinol quickly induced tolerance to their hypothermic effects in mice. Tolerance also developed to their pentobarbital-induced sleep prolongating effects. However, the degrees of tolerance development differed from one another. The sleeping times after the 8th injection of these cannabinoids were still significantly longer than those of the controls when no hypothermia was induced.

Original languageEnglish
Pages (from-to)53-56
Number of pages4
JournalEuropean Journal of Pharmacology
Volume77
Issue number1
DOIs
Publication statusPublished - Jan 8 1982

Keywords

  • 11-Hydroxy-Δ-tetrahydrocannabinol
  • 11-Oxo-Δ-tetrahydrocannabinol
  • Hypothermia
  • Pentobarbital-induced sleeping time
  • Tolerance
  • Δ-Tetrahydrocannabinol

ASJC Scopus subject areas

  • Pharmacology

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