Daily administration (5 mg/kg i.v.) of 11-hydroxy-Δ8-tetrahydrocannabinol or 11-oxo-Δ8-tetrahydrocannabinol as well Δ8-tetrahydrocannabinol quickly induced tolerance to their hypothermic effects in mice. Tolerance also developed to their pentobarbital-induced sleep prolongating effects. However, the degrees of tolerance development differed from one another. The sleeping times after the 8th injection of these cannabinoids were still significantly longer than those of the controls when no hypothermia was induced.
- Pentobarbital-induced sleeping time
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