Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice

Possible role in protection against chemical carcinogenesis and toxicity

Mohammad Iqbal, Som Datta Sharma, Yasumasa Okazaki, Masayoshi Fujisawa, Shigeru Okada

Research output: Contribution to journalArticle

213 Citations (Scopus)

Abstract

Dietary antioxidants protect laboratory animals against the induction of tumours by a variety of chemical carcinogens. Among possible mechanism of protection against chemical carcinogenesis could be mediated via-antioxidant-dependent induction of detoxifying enzymes. Curcumin, a yellow pigment from Curcuma longa, is a major component of turmeric and is commonly used as a spice and food colouring material and exhibits antiinflammatory, antitumour, and antioxidant properties. In this study we therefore investigated the effect of dietary supplementation of curcumin on the activities of antioxidant and phase II-metabolizing enzymes involved in detoxification, and production of reactive oxygen species were quantified in ddY male mice. Dietary supplementation of curcumin (2%, w/v) to male ddY mice for 30 days significantly increased the activities of glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase and catalase to 189%, 179%, 189%, and 181% in liver and 143%, 134%, 167% and 115% in kidney respectively as compared with corresponding normal diet fed control (P

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalPharmacology and Toxicology
Volume92
Issue number1
DOIs
Publication statusPublished - Jan 1 2003

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Curcumin
Dietary Supplements
Toxicity
Carcinogenesis
Antioxidants
Curcuma
Enzymes
Spices
Detoxification
Enzyme Induction
Glutathione Reductase
Glucosephosphate Dehydrogenase
Laboratory Animals
Coloring
Nutrition
Glutathione Peroxidase
Pigments
Carcinogens
Liver
Catalase

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice : Possible role in protection against chemical carcinogenesis and toxicity. / Iqbal, Mohammad; Sharma, Som Datta; Okazaki, Yasumasa; Fujisawa, Masayoshi; Okada, Shigeru.

In: Pharmacology and Toxicology, Vol. 92, No. 1, 01.01.2003, p. 33-38.

Research output: Contribution to journalArticle

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