Dietary salt restriction improves cardiac and adipose tissue pathology independently of obesity in a rat model of metabolic syndrome

Takuya Hattori, Tamayo Murase, Miwa Takatsu, Kai Nagasawa, Natsumi Matsuura, Shogo Watanabe, Toyoaki Murohara, Kohzo Nagata

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background-Metabolic syndrome (MetS) enhances salt sensitivity of blood pressure and is an important risk factor for cardiovascular disease. The effects of dietary salt restriction on cardiac pathology associated with metabolic syndrome remain unclear. Methods and Results-We investigated whether dietary salt restriction might ameliorate cardiac injury in DahlS.Z-Leprfa/Leprfa (DS/obese) rats, which are derived from a cross between Dahl salt-sensitive and Zucker rats and represent a model of metabolic syndrome. DS/obese rats were fed a normal-salt (0.36% NaCl in chow) or low-salt (0.0466% NaCl in chow) diet from 9 weeks of age and were compared with similarly treated homozygous lean littermates (DahlS.Z-Lepr+/Lepr+, or DS/lean rats). DS/obese rats fed the normal-salt diet progressively developed hypertension and showed left ventricular hypertrophy, fibrosis, and diastolic dysfunction at 15 weeks. Dietary salt restriction attenuated all of these changes in DS/obese rats. The levels of cardiac oxidative stress and inflammation and the expression of cardiac renin-angiotensin-aldosterone system genes were increased in DS/obese rats fed the normal-salt diet, and dietary salt restriction downregulated these parameters in both DS/obese and DS/lean rats. In addition, dietary salt restriction attenuated the increase in visceral adipose tissue inflammation and the decrease in insulin signaling apparent in DS/obese rats without reducing body weight or visceral adipocyte size. Dietary salt restriction did not alter fasting serum glucose levels but it markedly decreased the fasting serum insulin concentration in DS/obese rats. Conclusions-Dietary salt restriction not only prevents hypertension and cardiac injury but also ameliorates insulin resistance, without reducing obesity, in this model of metabolic syndrome.

Original languageEnglish
Article number001312
JournalJournal of the American Heart Association
Volume3
Issue number6
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Adipose Tissue
Obesity
Salts
Pathology
Diet
Fasting
Inbred Dahl Rats
Insulin
Hypertension
Inflammation
Zucker Rats
Intra-Abdominal Fat
Wounds and Injuries
Left Ventricular Hypertrophy
Renin-Angiotensin System
Serum
Adipocytes
Insulin Resistance
Oxidative Stress
Fibrosis

Keywords

  • Diet
  • Hypertension
  • Obesity
  • Remodeling
  • Sodium

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Dietary salt restriction improves cardiac and adipose tissue pathology independently of obesity in a rat model of metabolic syndrome. / Hattori, Takuya; Murase, Tamayo; Takatsu, Miwa; Nagasawa, Kai; Matsuura, Natsumi; Watanabe, Shogo; Murohara, Toyoaki; Nagata, Kohzo.

In: Journal of the American Heart Association, Vol. 3, No. 6, 001312, 2014.

Research output: Contribution to journalArticle

Hattori, Takuya ; Murase, Tamayo ; Takatsu, Miwa ; Nagasawa, Kai ; Matsuura, Natsumi ; Watanabe, Shogo ; Murohara, Toyoaki ; Nagata, Kohzo. / Dietary salt restriction improves cardiac and adipose tissue pathology independently of obesity in a rat model of metabolic syndrome. In: Journal of the American Heart Association. 2014 ; Vol. 3, No. 6.
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