Dietary ginger constituents, galanals A and B, are potent apoptosis inducers in Human T lymphoma Jurkat cells

Noriyuki Miyoshi; Yoshimasa Nakamura; Yasuhiro Ueda; Masako Abe; Yoshio Ozawa; Koji Uchida; Toshihiko Osawa

doi:10.1016/S0304-3835(03)00381-1

Dietary ginger constituents, galanals A and B, are potent apoptosis inducers in Human T lymphoma Jurkat cells

Noriyuki Miyoshi, Yoshimasa Nakamura, Yasuhiro Ueda, Masako Abe, Yoshio Ozawa, Koji Uchida, Toshihiko Osawa

Research output: Contribution to journal › Article › peer-review

90 Citations (Scopus)

Abstract

The effects of the constituents isolated from ginger species including curcumin, 6-gingerol and labdane-type diterpene compounds on cell proliferation and the induction of apoptosis in the cultured human T lymphoma Jurkat cells were studied. Among the tested compounds, Galanals A and B, isolated from the flower buds of a Japanese ginger, myoga (Zingiber mioga Roscoe), showed the most potent cytotoxic effect. Exposure of Jurkat human T-cell leukemia cells to galanals resulted in the induction of apoptotic cell death characterized by DNA fragmentation and caspase-3 activation. The mitochondrial damage pathway was suggested to be involved in galanal-induced apoptosis because the treatment of cells with galanals induced mitochondrial transmembrane potential (ΔΨm) alteration and cytochrome c release. The anti-apoptotic Bcl-2 protein was downregulated by the galanal treatment together with enhancement of the Bax expression. In conclusion, the results from this study provide biological evidence that ginger-specific constituents other than curcuminoids are potential anticancer agents.

Original language	English
Pages (from-to)	113-119
Number of pages	7
Journal	Cancer Letters
Volume	199
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(03)00381-1
Publication status	Published - Sep 25 2003
Externally published	Yes

Keywords

Apoptosis
Curcumin
Galanal
Ginger
Jurkat cells
[6]-gingerol

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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title = "Dietary ginger constituents, galanals A and B, are potent apoptosis inducers in Human T lymphoma Jurkat cells",

abstract = "The effects of the constituents isolated from ginger species including curcumin, 6-gingerol and labdane-type diterpene compounds on cell proliferation and the induction of apoptosis in the cultured human T lymphoma Jurkat cells were studied. Among the tested compounds, Galanals A and B, isolated from the flower buds of a Japanese ginger, myoga (Zingiber mioga Roscoe), showed the most potent cytotoxic effect. Exposure of Jurkat human T-cell leukemia cells to galanals resulted in the induction of apoptotic cell death characterized by DNA fragmentation and caspase-3 activation. The mitochondrial damage pathway was suggested to be involved in galanal-induced apoptosis because the treatment of cells with galanals induced mitochondrial transmembrane potential (ΔΨm) alteration and cytochrome c release. The anti-apoptotic Bcl-2 protein was downregulated by the galanal treatment together with enhancement of the Bax expression. In conclusion, the results from this study provide biological evidence that ginger-specific constituents other than curcuminoids are potential anticancer agents.",

keywords = "Apoptosis, Curcumin, Galanal, Ginger, Jurkat cells, [6]-gingerol",

author = "Noriyuki Miyoshi and Yoshimasa Nakamura and Yasuhiro Ueda and Masako Abe and Yoshio Ozawa and Koji Uchida and Toshihiko Osawa",

note = "Funding Information: This study was supported by grants-in-aid for the Encouragement of Young Scientists (B) (No. 13760102) and in part by Special Coodination Funds of the Ministry of Education, Culture, Sports, Science and Technology, the Japanese Government and by the COE Program in the 21st Century in Japan.",

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doi = "10.1016/S0304-3835(03)00381-1",

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volume = "199",

pages = "113--119",

journal = "Cancer Letters",

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T1 - Dietary ginger constituents, galanals A and B, are potent apoptosis inducers in Human T lymphoma Jurkat cells

AU - Miyoshi, Noriyuki

AU - Nakamura, Yoshimasa

AU - Ueda, Yasuhiro

AU - Abe, Masako

AU - Ozawa, Yoshio

AU - Uchida, Koji

AU - Osawa, Toshihiko

N1 - Funding Information: This study was supported by grants-in-aid for the Encouragement of Young Scientists (B) (No. 13760102) and in part by Special Coodination Funds of the Ministry of Education, Culture, Sports, Science and Technology, the Japanese Government and by the COE Program in the 21st Century in Japan.

PY - 2003/9/25

Y1 - 2003/9/25

N2 - The effects of the constituents isolated from ginger species including curcumin, 6-gingerol and labdane-type diterpene compounds on cell proliferation and the induction of apoptosis in the cultured human T lymphoma Jurkat cells were studied. Among the tested compounds, Galanals A and B, isolated from the flower buds of a Japanese ginger, myoga (Zingiber mioga Roscoe), showed the most potent cytotoxic effect. Exposure of Jurkat human T-cell leukemia cells to galanals resulted in the induction of apoptotic cell death characterized by DNA fragmentation and caspase-3 activation. The mitochondrial damage pathway was suggested to be involved in galanal-induced apoptosis because the treatment of cells with galanals induced mitochondrial transmembrane potential (ΔΨm) alteration and cytochrome c release. The anti-apoptotic Bcl-2 protein was downregulated by the galanal treatment together with enhancement of the Bax expression. In conclusion, the results from this study provide biological evidence that ginger-specific constituents other than curcuminoids are potential anticancer agents.

AB - The effects of the constituents isolated from ginger species including curcumin, 6-gingerol and labdane-type diterpene compounds on cell proliferation and the induction of apoptosis in the cultured human T lymphoma Jurkat cells were studied. Among the tested compounds, Galanals A and B, isolated from the flower buds of a Japanese ginger, myoga (Zingiber mioga Roscoe), showed the most potent cytotoxic effect. Exposure of Jurkat human T-cell leukemia cells to galanals resulted in the induction of apoptotic cell death characterized by DNA fragmentation and caspase-3 activation. The mitochondrial damage pathway was suggested to be involved in galanal-induced apoptosis because the treatment of cells with galanals induced mitochondrial transmembrane potential (ΔΨm) alteration and cytochrome c release. The anti-apoptotic Bcl-2 protein was downregulated by the galanal treatment together with enhancement of the Bax expression. In conclusion, the results from this study provide biological evidence that ginger-specific constituents other than curcuminoids are potential anticancer agents.

KW - Apoptosis

KW - Curcumin

KW - Galanal

KW - Ginger

KW - Jurkat cells

KW - [6]-gingerol

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Dietary ginger constituents, galanals A and B, are potent apoptosis inducers in Human T lymphoma Jurkat cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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