Dietary ginger constituents, galanals A and B, are potent apoptosis inducers in Human T lymphoma Jurkat cells

Noriyuki Miyoshi, Yoshimasa Nakamura, Yasuhiro Ueda, Masako Abe, Yoshio Ozawa, Koji Uchida, Toshihiko Osawa

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

The effects of the constituents isolated from ginger species including curcumin, 6-gingerol and labdane-type diterpene compounds on cell proliferation and the induction of apoptosis in the cultured human T lymphoma Jurkat cells were studied. Among the tested compounds, Galanals A and B, isolated from the flower buds of a Japanese ginger, myoga (Zingiber mioga Roscoe), showed the most potent cytotoxic effect. Exposure of Jurkat human T-cell leukemia cells to galanals resulted in the induction of apoptotic cell death characterized by DNA fragmentation and caspase-3 activation. The mitochondrial damage pathway was suggested to be involved in galanal-induced apoptosis because the treatment of cells with galanals induced mitochondrial transmembrane potential (ΔΨm) alteration and cytochrome c release. The anti-apoptotic Bcl-2 protein was downregulated by the galanal treatment together with enhancement of the Bax expression. In conclusion, the results from this study provide biological evidence that ginger-specific constituents other than curcuminoids are potential anticancer agents.

Original languageEnglish
Pages (from-to)113-119
Number of pages7
JournalCancer Letters
Volume199
Issue number2
DOIs
Publication statusPublished - Sep 25 2003
Externally publishedYes

Keywords

  • Apoptosis
  • Curcumin
  • Galanal
  • Ginger
  • Jurkat cells
  • [6]-gingerol

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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