Dicobalt Octacarbonyl Promoted Rearrangement of 4-Isoxazolines to Acylaziridines: Dramatic Rate Acceleration with Very High Substrate Tolerance

Teruhiko Ishikawa, Takayuki Kudoh, Juri Yoshida, Ayako Yasuhara, Shinobu Manabe, Seiki Saito

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Abstract

(Matrix Presented) Dicobalt octacarbonyl [Co2(CO)8] in acetonitrile at 75 °C triggers the cleavage of the N-O bond of 4-isoxazolines (1) to bring about the valence rearrangement to 2-acylaziridines (2). The isoxazolines were stable at 75 °C in the absence of the cobalt complex.

Original languageEnglish
Pages (from-to)1907-1910
Number of pages4
JournalOrganic Letters
Volume4
Issue number11
DOIs
Publication statusPublished - May 30 2002

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ASJC Scopus subject areas

  • Molecular Medicine

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