Dicobalt Octacarbonyl Promoted Rearrangement of 4-Isoxazolines to Acylaziridines

Dramatic Rate Acceleration with Very High Substrate Tolerance

Teruhiko Ishikawa, Takayuki Kudoh, Juri Yoshida, Ayako Yasuhara, Shinobu Manabe, Seiki Saito

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

(Matrix Presented) Dicobalt octacarbonyl [Co2(CO)8] in acetonitrile at 75 °C triggers the cleavage of the N-O bond of 4-isoxazolines (1) to bring about the valence rearrangement to 2-acylaziridines (2). The isoxazolines were stable at 75 °C in the absence of the cobalt complex.

Original languageEnglish
Pages (from-to)1907-1910
Number of pages4
JournalOrganic Letters
Volume4
Issue number11
DOIs
Publication statusPublished - May 30 2002

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Cobalt
acetonitrile
cleavage
cobalt
actuators
valence
Substrates
matrices
dicobalt octacarbonyl

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Dicobalt Octacarbonyl Promoted Rearrangement of 4-Isoxazolines to Acylaziridines : Dramatic Rate Acceleration with Very High Substrate Tolerance. / Ishikawa, Teruhiko; Kudoh, Takayuki; Yoshida, Juri; Yasuhara, Ayako; Manabe, Shinobu; Saito, Seiki.

In: Organic Letters, Vol. 4, No. 11, 30.05.2002, p. 1907-1910.

Research output: Contribution to journalArticle

Ishikawa, Teruhiko ; Kudoh, Takayuki ; Yoshida, Juri ; Yasuhara, Ayako ; Manabe, Shinobu ; Saito, Seiki. / Dicobalt Octacarbonyl Promoted Rearrangement of 4-Isoxazolines to Acylaziridines : Dramatic Rate Acceleration with Very High Substrate Tolerance. In: Organic Letters. 2002 ; Vol. 4, No. 11. pp. 1907-1910.
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