Diagnostic value of Thallium-201 scintigraphy in differentiating malignant bone tumors from benign bone lesions

Ryota Inai, Takayoshi Shinya, Akihiro Tada, Shuhei Sato, Tomohiro Fujiwara, Ken Takeda, Toshiyuki Kunisada, Hiroyuki Yanai, Toshihumi Ozaki, Susumu Kanazawa

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4 Citations (Scopus)


Objective: This retrospective study aims to evaluate the diagnostic capacity of thallium-201 (201Tl) scintigraphy for differentiating malignant bone tumors from benign bone lesions. Methods: Between January 2006 and December 2012, 279 patients with bone lesions (51 malignant and 228 benign) underwent 201Tl scintigraphy before treatment. To evaluate 201Tl uptake, we investigated tumor-to-background contrast (TBC) as well as TBC washout rate (WR). The differences of TBC on early and delayed images and WR were estimated by the Mann–Whitney U test. Receiver operating characteristic (ROC) analyses were used to determine the cut-off TBC values for differentiating malignant bone tumors from benign bone lesions. Results: There were statistically significant differences in median TBC between malignant tumors and benign lesions. These differences occurred for early imaging (1.57 vs. 0.09, p 

Original languageEnglish
Pages (from-to)674-681
Number of pages8
JournalAnnals of Nuclear Medicine
Issue number8
Publication statusPublished - Jun 3 2015



  • Benign bone tumor
  • Malignant bone tumor
  • Receiver operating characteristic (ROC) analysis
  • Thallium-201 scintigraphy
  • Tumor-to-background contrast (TBC)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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