Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors

Miki Hisatomi, Jun-Ichi Asaumi, Yoshinobu Yanagi, Teruhisa Unetsubo, Yuu Maki, Jun Murakami, Hidenobu Matsuzaki, Yasutoshi Honda, Hironobu Konouchi

Research output: Contribution to journalArticle

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Abstract

To evaluate the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) in salivary gland tumors, thirty-five patients (47 lesions) who underwent MR examinations and were histopathologically diagnosed with salivary gland tumors in Okayama University Hospital, between April 1998 and March 2005, were entered in the present study. The parameters included CImax300 or CImax600, which was the contrast index (CI) at maximal contrast enhancement upon 300 s or 600 s, and Tmax, which was the time that corresponded to the CImax300. Washout ratio (WR300 or WR600) was defined as follows: CImax300 - CI300s/CImax300 or CImax600 - CI600s/CImax600 × 100 (%), where CI300 or CI600 was the CI at 300 s or 600 s after contrast medium administration. We obtained the following results from the analysis of DCE-MRI parameters; (a) The salivary gland tumors were categorized into three CI curve types according to Tmax and WR300; Pleomorphic adenoma; Tmax > 210 s and WR300 <10%, Warthin tumor; Tmax <60 s and WR300 > 40%, and malignant tumor; 60 s <Tmax <210 s and 10% <WR300 <30%; (b) On the basis of the relationship between Tmax and CImax or WR, all pleomorphic adenomas were successfully differentiated from Warthin tumor lesions. Of the 20 pleomorphic adenomas, 18 (90.0%) were successfully differentiated from malignant tumors. All Warthin tumor lesions were successfully differentiated from pleomorphic adenomas and malignant tumors. Of 12 the malignant tumors, 11 (91.7%) were successfully differentiated from pleomorphic adenomas. All malignant tumors were successfully differentiated from Warthin tumors. Thus, DCE-MRI parameters are useful in diagnosing salivary gland tumors on the basis of the combined assessment of Tmax and CImax or WR.

Original languageEnglish
Pages (from-to)940-947
Number of pages8
JournalOral Oncology
Volume43
Issue number9
DOIs
Publication statusPublished - Oct 2007

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Pleomorphic Adenoma
Glandular and Epithelial Neoplasms
Adenolymphoma
Neoplasms
Contrast Media

Keywords

  • Adenoid cystic carcinoma
  • DCE-MRI
  • Mucoepidermoid carcinoma
  • Pleomorphic adenoma
  • Warthin tumor

ASJC Scopus subject areas

  • Oncology

Cite this

Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors. / Hisatomi, Miki; Asaumi, Jun-Ichi; Yanagi, Yoshinobu; Unetsubo, Teruhisa; Maki, Yuu; Murakami, Jun; Matsuzaki, Hidenobu; Honda, Yasutoshi; Konouchi, Hironobu.

In: Oral Oncology, Vol. 43, No. 9, 10.2007, p. 940-947.

Research output: Contribution to journalArticle

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abstract = "To evaluate the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) in salivary gland tumors, thirty-five patients (47 lesions) who underwent MR examinations and were histopathologically diagnosed with salivary gland tumors in Okayama University Hospital, between April 1998 and March 2005, were entered in the present study. The parameters included CImax300 or CImax600, which was the contrast index (CI) at maximal contrast enhancement upon 300 s or 600 s, and Tmax, which was the time that corresponded to the CImax300. Washout ratio (WR300 or WR600) was defined as follows: CImax300 - CI300s/CImax300 or CImax600 - CI600s/CImax600 × 100 ({\%}), where CI300 or CI600 was the CI at 300 s or 600 s after contrast medium administration. We obtained the following results from the analysis of DCE-MRI parameters; (a) The salivary gland tumors were categorized into three CI curve types according to Tmax and WR300; Pleomorphic adenoma; Tmax > 210 s and WR300 <10{\%}, Warthin tumor; Tmax <60 s and WR300 > 40{\%}, and malignant tumor; 60 s <Tmax <210 s and 10{\%} <WR300 <30{\%}; (b) On the basis of the relationship between Tmax and CImax or WR, all pleomorphic adenomas were successfully differentiated from Warthin tumor lesions. Of the 20 pleomorphic adenomas, 18 (90.0{\%}) were successfully differentiated from malignant tumors. All Warthin tumor lesions were successfully differentiated from pleomorphic adenomas and malignant tumors. Of 12 the malignant tumors, 11 (91.7{\%}) were successfully differentiated from pleomorphic adenomas. All malignant tumors were successfully differentiated from Warthin tumors. Thus, DCE-MRI parameters are useful in diagnosing salivary gland tumors on the basis of the combined assessment of Tmax and CImax or WR.",
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AU - Maki, Yuu

AU - Murakami, Jun

AU - Matsuzaki, Hidenobu

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AB - To evaluate the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) in salivary gland tumors, thirty-five patients (47 lesions) who underwent MR examinations and were histopathologically diagnosed with salivary gland tumors in Okayama University Hospital, between April 1998 and March 2005, were entered in the present study. The parameters included CImax300 or CImax600, which was the contrast index (CI) at maximal contrast enhancement upon 300 s or 600 s, and Tmax, which was the time that corresponded to the CImax300. Washout ratio (WR300 or WR600) was defined as follows: CImax300 - CI300s/CImax300 or CImax600 - CI600s/CImax600 × 100 (%), where CI300 or CI600 was the CI at 300 s or 600 s after contrast medium administration. We obtained the following results from the analysis of DCE-MRI parameters; (a) The salivary gland tumors were categorized into three CI curve types according to Tmax and WR300; Pleomorphic adenoma; Tmax > 210 s and WR300 <10%, Warthin tumor; Tmax <60 s and WR300 > 40%, and malignant tumor; 60 s <Tmax <210 s and 10% <WR300 <30%; (b) On the basis of the relationship between Tmax and CImax or WR, all pleomorphic adenomas were successfully differentiated from Warthin tumor lesions. Of the 20 pleomorphic adenomas, 18 (90.0%) were successfully differentiated from malignant tumors. All Warthin tumor lesions were successfully differentiated from pleomorphic adenomas and malignant tumors. Of 12 the malignant tumors, 11 (91.7%) were successfully differentiated from pleomorphic adenomas. All malignant tumors were successfully differentiated from Warthin tumors. Thus, DCE-MRI parameters are useful in diagnosing salivary gland tumors on the basis of the combined assessment of Tmax and CImax or WR.

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