Diagnostic value of dynamic contrast-enhanced MRI for submucosal palatal tumors

Hidenobu Matsuzaki, Yoshinobu Yanagi, Marina Hara, Naoki Katase, Miki Hisatomi, Teruhisa Unetsubo, Hironobu Konouchi, Toshihiko Takenobu, Hitoshi Nagatsuka, Jun-Ichi Asaumi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objectives: To evaluate the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) for differentiating between benign and malignant tumors in the palate. Materials and methods: 26 patients with submucosal palatal tumors were preoperatively examined using DCE-MRI. Their maximum contrast index (CImax), time of CImax (Tmax), and washout ratios (WR300 and WR600) were determined from contrast index curves. The submucosal palatal tumors were divided into two groups according to their Tmax values: the early enhancement group (Tmax <300 s) consisted of 9 malignant tumors and 6 benign tumors, while the late enhancement group (Tmax ≥ 300 s) included one malignant tumor and 10 benign tumors. We compared the following DCE-MRI parameters between the benign and malignant tumors: CImax and Tmax in all cases and CImax, Tmax, and the washout ratios in the early enhancement group. In addition, we performed a regression analysis of the relationships between tumor size and DCE-MRI parameters; i.e., CImax, Tmax, and washout ratios, among the malignant salivary gland tumors and pleomorphic adenomas. Results: In all cases and the early enhancement group, significant differences in Tmax were detected between the benign and malignant tumors (P <0.001 and P <0.05, respectively), and the optimal Tmax cutoff value for differentiating between them was found to be 165 s. None of the other parameters displayed significant differences between the benign and malignant tumors. Only the WR600 of the pleomorphic adenomas was significantly correlated with tumor size (R2 = 0.92, P <0.001). Conclusions: Tmax is a useful parameter for distinguishing between benign and malignant submucosal palatal tumors.

Original languageEnglish
Pages (from-to)3306-3312
Number of pages7
JournalEuropean Journal of Radiology
Volume81
Issue number11
DOIs
Publication statusPublished - Nov 2012

    Fingerprint

Keywords

  • Dynamic MRI
  • Malignant lymphoma
  • Minor salivary gland tumor
  • MRI
  • Palate tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this