Diagnostic value of dual-time-point F-18 FDG PET/CT and chest CT for the prediction of thymic epithelial neoplasmsw

Takayoshi Shinya, Takashi Tanaka, Junichi Sou, Toshi Matsushita, Shuhei Sato, Shinichi Toyooka, Tadashi Yoshino, Shinichiro Miyoshi, Susumu Kanazawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We retrospectively assessed the dual-time-point (DTP) F-18 FDG PET/CT findings of thymic epithelial neoplasms (TENs) and investigated the diagnostic capacity of PET/CT compared to that of CT for predicting carcinoma. We calculated the ratio of the standardized uptake value of the tumor and that of the aortic arch (T/M ratio) for both the 90-min early scan and the 2-h delayed scan in 56 TEN patients. We used a multivariate logistic regression (MLR) analysis to estimate the CT features of carcinoma. We compared the diagnostic capacities of PET/CT and chest CT using receiver operating characteristic (ROC) analyses. The ROC curve revealed that the appropriate cut-off T/M ratio value for the highest accuracy was 2.39 with 75.0% accuracy. The area under the curve (AUC) was 0.855. The statistical analyses for DTP scans of 35 TEN patients demonstrated 74.3% accuracy and 0.838 AUC for the early scan versus 82.9% and 0.825 for the delayed scan. The MLR analysis indicated that mediastinal fat infiltration was a predictor of carcinoma. The ROC curve obtained for the model yielded an AUC of 0.853. Delayed scanning could improve the diagnostic capacity for carcinoma. The T/M ratio and mediastinal fat infiltration are predictive of carcinoma with moderate diagnostic accuracy.

Original languageEnglish
Pages (from-to)105-112
Number of pages8
JournalActa Medica Okayama
Volume71
Issue number2
Publication statusPublished - 2017

Fingerprint

Infiltration
Regression analysis
Logistics
Thymus Neoplasms
Thorax
Fats
Glandular and Epithelial Neoplasms
Carcinoma
ROC Curve
Area Under Curve
Arches
Tumors
Scanning
Logistic Models
Regression Analysis
Thoracic Aorta
Neoplasms

Keywords

  • Chest CT
  • Dual-time-point PET/CT
  • Thymic carcinoma
  • Thymic epithelial neoplasm
  • Thymoma

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

@article{7cc6d677ad0344409047059561983dfb,
title = "Diagnostic value of dual-time-point F-18 FDG PET/CT and chest CT for the prediction of thymic epithelial neoplasmsw",
abstract = "We retrospectively assessed the dual-time-point (DTP) F-18 FDG PET/CT findings of thymic epithelial neoplasms (TENs) and investigated the diagnostic capacity of PET/CT compared to that of CT for predicting carcinoma. We calculated the ratio of the standardized uptake value of the tumor and that of the aortic arch (T/M ratio) for both the 90-min early scan and the 2-h delayed scan in 56 TEN patients. We used a multivariate logistic regression (MLR) analysis to estimate the CT features of carcinoma. We compared the diagnostic capacities of PET/CT and chest CT using receiver operating characteristic (ROC) analyses. The ROC curve revealed that the appropriate cut-off T/M ratio value for the highest accuracy was 2.39 with 75.0{\%} accuracy. The area under the curve (AUC) was 0.855. The statistical analyses for DTP scans of 35 TEN patients demonstrated 74.3{\%} accuracy and 0.838 AUC for the early scan versus 82.9{\%} and 0.825 for the delayed scan. The MLR analysis indicated that mediastinal fat infiltration was a predictor of carcinoma. The ROC curve obtained for the model yielded an AUC of 0.853. Delayed scanning could improve the diagnostic capacity for carcinoma. The T/M ratio and mediastinal fat infiltration are predictive of carcinoma with moderate diagnostic accuracy.",
keywords = "Chest CT, Dual-time-point PET/CT, Thymic carcinoma, Thymic epithelial neoplasm, Thymoma",
author = "Takayoshi Shinya and Takashi Tanaka and Junichi Sou and Toshi Matsushita and Shuhei Sato and Shinichi Toyooka and Tadashi Yoshino and Shinichiro Miyoshi and Susumu Kanazawa",
year = "2017",
language = "English",
volume = "71",
pages = "105--112",
journal = "Acta Medica Okayama",
issn = "0386-300X",
publisher = "Okayama University",
number = "2",

}

TY - JOUR

T1 - Diagnostic value of dual-time-point F-18 FDG PET/CT and chest CT for the prediction of thymic epithelial neoplasmsw

AU - Shinya, Takayoshi

AU - Tanaka, Takashi

AU - Sou, Junichi

AU - Matsushita, Toshi

AU - Sato, Shuhei

AU - Toyooka, Shinichi

AU - Yoshino, Tadashi

AU - Miyoshi, Shinichiro

AU - Kanazawa, Susumu

PY - 2017

Y1 - 2017

N2 - We retrospectively assessed the dual-time-point (DTP) F-18 FDG PET/CT findings of thymic epithelial neoplasms (TENs) and investigated the diagnostic capacity of PET/CT compared to that of CT for predicting carcinoma. We calculated the ratio of the standardized uptake value of the tumor and that of the aortic arch (T/M ratio) for both the 90-min early scan and the 2-h delayed scan in 56 TEN patients. We used a multivariate logistic regression (MLR) analysis to estimate the CT features of carcinoma. We compared the diagnostic capacities of PET/CT and chest CT using receiver operating characteristic (ROC) analyses. The ROC curve revealed that the appropriate cut-off T/M ratio value for the highest accuracy was 2.39 with 75.0% accuracy. The area under the curve (AUC) was 0.855. The statistical analyses for DTP scans of 35 TEN patients demonstrated 74.3% accuracy and 0.838 AUC for the early scan versus 82.9% and 0.825 for the delayed scan. The MLR analysis indicated that mediastinal fat infiltration was a predictor of carcinoma. The ROC curve obtained for the model yielded an AUC of 0.853. Delayed scanning could improve the diagnostic capacity for carcinoma. The T/M ratio and mediastinal fat infiltration are predictive of carcinoma with moderate diagnostic accuracy.

AB - We retrospectively assessed the dual-time-point (DTP) F-18 FDG PET/CT findings of thymic epithelial neoplasms (TENs) and investigated the diagnostic capacity of PET/CT compared to that of CT for predicting carcinoma. We calculated the ratio of the standardized uptake value of the tumor and that of the aortic arch (T/M ratio) for both the 90-min early scan and the 2-h delayed scan in 56 TEN patients. We used a multivariate logistic regression (MLR) analysis to estimate the CT features of carcinoma. We compared the diagnostic capacities of PET/CT and chest CT using receiver operating characteristic (ROC) analyses. The ROC curve revealed that the appropriate cut-off T/M ratio value for the highest accuracy was 2.39 with 75.0% accuracy. The area under the curve (AUC) was 0.855. The statistical analyses for DTP scans of 35 TEN patients demonstrated 74.3% accuracy and 0.838 AUC for the early scan versus 82.9% and 0.825 for the delayed scan. The MLR analysis indicated that mediastinal fat infiltration was a predictor of carcinoma. The ROC curve obtained for the model yielded an AUC of 0.853. Delayed scanning could improve the diagnostic capacity for carcinoma. The T/M ratio and mediastinal fat infiltration are predictive of carcinoma with moderate diagnostic accuracy.

KW - Chest CT

KW - Dual-time-point PET/CT

KW - Thymic carcinoma

KW - Thymic epithelial neoplasm

KW - Thymoma

UR - http://www.scopus.com/inward/record.url?scp=85017421518&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017421518&partnerID=8YFLogxK

M3 - Article

VL - 71

SP - 105

EP - 112

JO - Acta Medica Okayama

JF - Acta Medica Okayama

SN - 0386-300X

IS - 2

ER -