Diagnostic validity of high-density barium sulfate in gastric cancer screening: Follow-up of Screenees by Record Linkage with the Osaka Cancer registry

Kenyu Yamamoto, Hideo Yamazaki, Chikazumi Kuroda, Tsugio Kubo, Akira Oshima, Toshizo Katsuda, Tadao Kuwano, Yoshihiro Takeda

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10 Citations (Scopus)


Background: The use of high-density barium sulfate was recommended by the Japan Society of Gastroenterological Cancer Screening (JSGCS) in 2004. We evaluated the diagnostic validity of gastric cancer screening that used high-density barium sulfate. Methods: The study subjects were 171 833 residents of Osaka, Japan who underwent gastric cancer screening tests at the Osaka Cancer Prevention and Detection Center during the period from 1 January 2000 through 31 December 2001. Screening was conducted using either high-density barium sulfate (n = 48 336) or moderate-density barium sulfate (n = 123 497). The subjects were followed up and their medical records were linked to those of the Osaka Cancer Registry through 31 December 2002. The results of follow-up during 1 year were defined as the gold standard, and test performance values were calculated. Results: The sensitivity and specificity of the screening test using moderate-density barium sulfate were 92.3% and 91.0%, respectively, while the sensitivity and specificity of the high-density barium test were 91.8% and 91.4%, respectively. The results of area under receiver-operating-characteristic (ROC) curve analysis revealed no significant difference between the 2 screening tests. Conclusions: Screening tests using high- and moderate-density barium sulfate had similar validity, as determined by sensitivity, specificity, and ROC curve analysis.

Original languageEnglish
Pages (from-to)287-294
Number of pages8
JournalJournal of Epidemiology
Issue number4
Publication statusPublished - 2010



  • Area under ROC curve (AUC) analysis
  • Barium sulfate
  • Gastric cancer screening
  • Sensitivity
  • Specificity

ASJC Scopus subject areas

  • Epidemiology
  • Medicine(all)

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