TY - JOUR
T1 - Diagnostic performance of IQ·SPECT with high-speed scanning
T2 - A preliminary quality control study in obese patients
AU - Werner, Rudolf A.
AU - Martinez, Ricardo Bello
AU - Marcus, Charles
AU - Kruse, Matthew J.
AU - Sheikhbahaei, Sara
AU - Solnes, Lilja B.
AU - Higuchi, Takahiro
AU - Javadi, Mehrbod S.
AU - Rowe, Steven P.
N1 - Funding Information:
This work was supported by German Research Council (Deutsche Forschungsgemeinschaft, 453989101, TH, RAW) and through the Okayama University “RECTOR” Program (TH). A KAKENHI Grant (21K19450) has been provided for TH from the Japan Society for the Promotion of Science (JSPS).
Publisher Copyright:
© 2022, The Author(s) under exclusive licence to American Society of Nuclear Cardiology.
PY - 2022
Y1 - 2022
N2 - Background: IQ·SPECT is a recently introduced collimator design for myocardial perfusion imaging (MPI). Little data exist on use of this collimator type in obese patients, particularly Class 2 or 3 [body mass index (BMI) > 35 kg/m2]. Methods: Two consecutive rest–stress MPI scans were prospectively acquired using a conventional collimator and IQ·SPECT (acquisition times of 20 and 7 minutes, respectively) in 20 patients with a BMI of >30 kg/m2. Assigned by two blinded, independent readers, image quality (on a 5-point scale) and metrics of myocardial perfusion [summed stress score (SSS), summed rest score (SRS) and summed difference score (SDS)] were compared. Software-based left ventricular ejection fraction (EF) was also correlated. Results: Mean BMI was 39.6 ± 7.6 kg/m2. Class 2 or 3 obesity was present in 12 patients (BMI, 44.1 ± 6.8 kg/m2). Gated/non-gated images from IQ·SPECT revealed fair to good quality scores (median ≥ 3.25), which were inferior to the conventional collimator (median ≥ 4.0; P ≤ 0.01). Significant correlative indices were achieved when comparing IQ·SPECT and conventional collimators for EF values (r = 0.86, P < 0.01), SSS (r = 0.75, P < 0.0001) and SRS (r = 0.60, P < 0.005), but not for SDS (r = 0.15). Conclusion: IQ·SPECT was comparable to conventional SPECT in obese patients. The reduced acquisition time of IQ·SPECT may allow for improved throughput with no loss in diagnostic accuracy.
AB - Background: IQ·SPECT is a recently introduced collimator design for myocardial perfusion imaging (MPI). Little data exist on use of this collimator type in obese patients, particularly Class 2 or 3 [body mass index (BMI) > 35 kg/m2]. Methods: Two consecutive rest–stress MPI scans were prospectively acquired using a conventional collimator and IQ·SPECT (acquisition times of 20 and 7 minutes, respectively) in 20 patients with a BMI of >30 kg/m2. Assigned by two blinded, independent readers, image quality (on a 5-point scale) and metrics of myocardial perfusion [summed stress score (SSS), summed rest score (SRS) and summed difference score (SDS)] were compared. Software-based left ventricular ejection fraction (EF) was also correlated. Results: Mean BMI was 39.6 ± 7.6 kg/m2. Class 2 or 3 obesity was present in 12 patients (BMI, 44.1 ± 6.8 kg/m2). Gated/non-gated images from IQ·SPECT revealed fair to good quality scores (median ≥ 3.25), which were inferior to the conventional collimator (median ≥ 4.0; P ≤ 0.01). Significant correlative indices were achieved when comparing IQ·SPECT and conventional collimators for EF values (r = 0.86, P < 0.01), SSS (r = 0.75, P < 0.0001) and SRS (r = 0.60, P < 0.005), but not for SDS (r = 0.15). Conclusion: IQ·SPECT was comparable to conventional SPECT in obese patients. The reduced acquisition time of IQ·SPECT may allow for improved throughput with no loss in diagnostic accuracy.
KW - image quality
KW - MPI
KW - myocardial perfusion imaging
KW - Single-photon emission computed tomography
KW - SPECT
UR - http://www.scopus.com/inward/record.url?scp=85127628935&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85127628935&partnerID=8YFLogxK
U2 - 10.1007/s12350-022-02928-3
DO - 10.1007/s12350-022-02928-3
M3 - Article
AN - SCOPUS:85127628935
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
SN - 1071-3581
ER -
