Diagnostic performance of chromoendoscopy and narrow band imaging for colonic neoplasms

A meta-analysis

Y. Kobayashi, Y. Hayashino, J. L. Jackson, N. Takagaki, S. Hinotsu, K. Kawakami

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Aim We conducted a meta-analysis to compare the diagnostic test performance of chromoendoscopy and narrow band imaging (NBI) for colonic neoplasms. Method MEDLINE, EMBASE and the Cochrane Library were searched (1966 to March 2009). Articles were included if: (i) chromoendoscopy or NBI was used, (ii) sensitivity and specificity were reported; (iii) absolute numbers of true-positive, false-positive, true-negative and false-negative results were provided or could be calculated; and (iv) pathology was used as the reference standard. Sensitivity and specificity were pooled using random effects model. Secondary analyses were conducted by limiting the studies in which magnifying endoscopy was used alone as a diagnostic modality, and polyp size and macroscopic appearance of lesions were not considered. Results Of 1342 screened articles, 27 met the inclusion criteria. Pooled sensitivity for chromoendoscopy and NBI was 0.94 (95% CI, 0.92-0.95) and 0.94 (0.91-0.97), and specificity was 0.82 (0.77-0.88) and 0.86 (0.83-0.89), respectively. There were no differences in sensitivity (P=0.99) or specificity (P=0.54) between the two methods. In the secondary analysis, pooled sensitivity for choromoendoscopy and NBI was 0.93 (95% CI, 0.90-0.97) and 0.96 (0.93-0.99) and specificity was 0.80 (0.73-0.87) and 0.85 (0.78-0.92). respectively. Overall, the pooled false-negative rate was 0.057 (95% CI, 0.040-0.73) for chromoendoscopy and 0.057 (95% CI, 0.028-0.085) for NBI. Conclusion Chromoendoscopy and NBI had similar diagnostic test characteristics in the assessment of colonic neoplasms; however, the false-negative rate for both methods of 5.7% is an unacceptably high rate and currently therefore, neither method is ready for general use.

Original languageEnglish
Pages (from-to)18-28
Number of pages11
JournalColorectal Disease
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 2012
Externally publishedYes

Fingerprint

Narrow Band Imaging
Colonic Neoplasms
Meta-Analysis
Routine Diagnostic Tests
Sensitivity and Specificity
Polyps
MEDLINE
Endoscopy
Libraries
Pathology

Keywords

  • Chromoendoscopy
  • Colorectal neoplasms
  • Narrow band imaging
  • Systematic review

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Kobayashi, Y., Hayashino, Y., Jackson, J. L., Takagaki, N., Hinotsu, S., & Kawakami, K. (2012). Diagnostic performance of chromoendoscopy and narrow band imaging for colonic neoplasms: A meta-analysis. Colorectal Disease, 14(1), 18-28. https://doi.org/10.1111/j.1463-1318.2010.02449.x

Diagnostic performance of chromoendoscopy and narrow band imaging for colonic neoplasms : A meta-analysis. / Kobayashi, Y.; Hayashino, Y.; Jackson, J. L.; Takagaki, N.; Hinotsu, S.; Kawakami, K.

In: Colorectal Disease, Vol. 14, No. 1, 01.2012, p. 18-28.

Research output: Contribution to journalArticle

Kobayashi, Y, Hayashino, Y, Jackson, JL, Takagaki, N, Hinotsu, S & Kawakami, K 2012, 'Diagnostic performance of chromoendoscopy and narrow band imaging for colonic neoplasms: A meta-analysis', Colorectal Disease, vol. 14, no. 1, pp. 18-28. https://doi.org/10.1111/j.1463-1318.2010.02449.x
Kobayashi, Y. ; Hayashino, Y. ; Jackson, J. L. ; Takagaki, N. ; Hinotsu, S. ; Kawakami, K. / Diagnostic performance of chromoendoscopy and narrow band imaging for colonic neoplasms : A meta-analysis. In: Colorectal Disease. 2012 ; Vol. 14, No. 1. pp. 18-28.
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abstract = "Aim We conducted a meta-analysis to compare the diagnostic test performance of chromoendoscopy and narrow band imaging (NBI) for colonic neoplasms. Method MEDLINE, EMBASE and the Cochrane Library were searched (1966 to March 2009). Articles were included if: (i) chromoendoscopy or NBI was used, (ii) sensitivity and specificity were reported; (iii) absolute numbers of true-positive, false-positive, true-negative and false-negative results were provided or could be calculated; and (iv) pathology was used as the reference standard. Sensitivity and specificity were pooled using random effects model. Secondary analyses were conducted by limiting the studies in which magnifying endoscopy was used alone as a diagnostic modality, and polyp size and macroscopic appearance of lesions were not considered. Results Of 1342 screened articles, 27 met the inclusion criteria. Pooled sensitivity for chromoendoscopy and NBI was 0.94 (95{\%} CI, 0.92-0.95) and 0.94 (0.91-0.97), and specificity was 0.82 (0.77-0.88) and 0.86 (0.83-0.89), respectively. There were no differences in sensitivity (P=0.99) or specificity (P=0.54) between the two methods. In the secondary analysis, pooled sensitivity for choromoendoscopy and NBI was 0.93 (95{\%} CI, 0.90-0.97) and 0.96 (0.93-0.99) and specificity was 0.80 (0.73-0.87) and 0.85 (0.78-0.92). respectively. Overall, the pooled false-negative rate was 0.057 (95{\%} CI, 0.040-0.73) for chromoendoscopy and 0.057 (95{\%} CI, 0.028-0.085) for NBI. Conclusion Chromoendoscopy and NBI had similar diagnostic test characteristics in the assessment of colonic neoplasms; however, the false-negative rate for both methods of 5.7{\%} is an unacceptably high rate and currently therefore, neither method is ready for general use.",
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AU - Hinotsu, S.

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N2 - Aim We conducted a meta-analysis to compare the diagnostic test performance of chromoendoscopy and narrow band imaging (NBI) for colonic neoplasms. Method MEDLINE, EMBASE and the Cochrane Library were searched (1966 to March 2009). Articles were included if: (i) chromoendoscopy or NBI was used, (ii) sensitivity and specificity were reported; (iii) absolute numbers of true-positive, false-positive, true-negative and false-negative results were provided or could be calculated; and (iv) pathology was used as the reference standard. Sensitivity and specificity were pooled using random effects model. Secondary analyses were conducted by limiting the studies in which magnifying endoscopy was used alone as a diagnostic modality, and polyp size and macroscopic appearance of lesions were not considered. Results Of 1342 screened articles, 27 met the inclusion criteria. Pooled sensitivity for chromoendoscopy and NBI was 0.94 (95% CI, 0.92-0.95) and 0.94 (0.91-0.97), and specificity was 0.82 (0.77-0.88) and 0.86 (0.83-0.89), respectively. There were no differences in sensitivity (P=0.99) or specificity (P=0.54) between the two methods. In the secondary analysis, pooled sensitivity for choromoendoscopy and NBI was 0.93 (95% CI, 0.90-0.97) and 0.96 (0.93-0.99) and specificity was 0.80 (0.73-0.87) and 0.85 (0.78-0.92). respectively. Overall, the pooled false-negative rate was 0.057 (95% CI, 0.040-0.73) for chromoendoscopy and 0.057 (95% CI, 0.028-0.085) for NBI. Conclusion Chromoendoscopy and NBI had similar diagnostic test characteristics in the assessment of colonic neoplasms; however, the false-negative rate for both methods of 5.7% is an unacceptably high rate and currently therefore, neither method is ready for general use.

AB - Aim We conducted a meta-analysis to compare the diagnostic test performance of chromoendoscopy and narrow band imaging (NBI) for colonic neoplasms. Method MEDLINE, EMBASE and the Cochrane Library were searched (1966 to March 2009). Articles were included if: (i) chromoendoscopy or NBI was used, (ii) sensitivity and specificity were reported; (iii) absolute numbers of true-positive, false-positive, true-negative and false-negative results were provided or could be calculated; and (iv) pathology was used as the reference standard. Sensitivity and specificity were pooled using random effects model. Secondary analyses were conducted by limiting the studies in which magnifying endoscopy was used alone as a diagnostic modality, and polyp size and macroscopic appearance of lesions were not considered. Results Of 1342 screened articles, 27 met the inclusion criteria. Pooled sensitivity for chromoendoscopy and NBI was 0.94 (95% CI, 0.92-0.95) and 0.94 (0.91-0.97), and specificity was 0.82 (0.77-0.88) and 0.86 (0.83-0.89), respectively. There were no differences in sensitivity (P=0.99) or specificity (P=0.54) between the two methods. In the secondary analysis, pooled sensitivity for choromoendoscopy and NBI was 0.93 (95% CI, 0.90-0.97) and 0.96 (0.93-0.99) and specificity was 0.80 (0.73-0.87) and 0.85 (0.78-0.92). respectively. Overall, the pooled false-negative rate was 0.057 (95% CI, 0.040-0.73) for chromoendoscopy and 0.057 (95% CI, 0.028-0.085) for NBI. Conclusion Chromoendoscopy and NBI had similar diagnostic test characteristics in the assessment of colonic neoplasms; however, the false-negative rate for both methods of 5.7% is an unacceptably high rate and currently therefore, neither method is ready for general use.

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