Diagnostic accuracy of endoscopic biopsies for the diagnosis of gastrointestinal follicular lymphoma: A clinicopathologic study of 48 patients

Masaya Iwamuro, Hiroyuki Okada, Katsuyoshi Takata, Soichiro Nose, Katsuya Miyatani, Tadashi Yoshino, Kazuhide Yamamoto

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The purpose of this study was to reveal the diagnostic accuracy of initial pathologic assessment of biopsied samples in patients with gastrointestinal follicular lymphoma lesions. A total of 48 patients with follicular lymphoma (Lugano system stage I: n = 30; II1: n = 4; II2: n = 4; IV: n = 10) with gastrointestinal involvement who underwent endoscopic biopsy were enrolled and retrospectively reviewed. Nine (18.8%) of the 48 patients were not appropriately diagnosed as having follicular lymphoma at the initial biopsy. The initial pathological diagnosis included extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (n = 4), necrotic tissue (n = 2), duodenitis (n = 1), or suspected lymphoma of unspecified subtype (n = 2). The reasons for these inappropriate diagnoses were insufficient histopathologic analysis lacking CD10 and BCL2 staining (n = 7) and unsuitable biopsy samples taken from erosions or ulcers that contained scanty lymphoma cells or no lymphoid follicles (n = 2). In conclusion, incomplete histopathologic analysis and unsuitable biopsy samples are pitfalls in the diagnosis of gastrointestinal follicular lymphoma.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalAnnals of Diagnostic Pathology
Volume18
Issue number2
DOIs
Publication statusPublished - 2014

Fingerprint

Follicular Lymphoma
Biopsy
Lymphoma
Duodenitis
Marginal Zone B-Cell Lymphoma
Ulcer
Staining and Labeling

Keywords

  • Biopsy
  • Duodenal neoplasms
  • Follicular lymphoma
  • Gastrointestinal endoscopes
  • Gastrointestinal lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Diagnostic accuracy of endoscopic biopsies for the diagnosis of gastrointestinal follicular lymphoma : A clinicopathologic study of 48 patients. / Iwamuro, Masaya; Okada, Hiroyuki; Takata, Katsuyoshi; Nose, Soichiro; Miyatani, Katsuya; Yoshino, Tadashi; Yamamoto, Kazuhide.

In: Annals of Diagnostic Pathology, Vol. 18, No. 2, 2014, p. 99-103.

Research output: Contribution to journalArticle

@article{1b32fa10859f49b7a60461f72a3d8ccd,
title = "Diagnostic accuracy of endoscopic biopsies for the diagnosis of gastrointestinal follicular lymphoma: A clinicopathologic study of 48 patients",
abstract = "The purpose of this study was to reveal the diagnostic accuracy of initial pathologic assessment of biopsied samples in patients with gastrointestinal follicular lymphoma lesions. A total of 48 patients with follicular lymphoma (Lugano system stage I: n = 30; II1: n = 4; II2: n = 4; IV: n = 10) with gastrointestinal involvement who underwent endoscopic biopsy were enrolled and retrospectively reviewed. Nine (18.8{\%}) of the 48 patients were not appropriately diagnosed as having follicular lymphoma at the initial biopsy. The initial pathological diagnosis included extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (n = 4), necrotic tissue (n = 2), duodenitis (n = 1), or suspected lymphoma of unspecified subtype (n = 2). The reasons for these inappropriate diagnoses were insufficient histopathologic analysis lacking CD10 and BCL2 staining (n = 7) and unsuitable biopsy samples taken from erosions or ulcers that contained scanty lymphoma cells or no lymphoid follicles (n = 2). In conclusion, incomplete histopathologic analysis and unsuitable biopsy samples are pitfalls in the diagnosis of gastrointestinal follicular lymphoma.",
keywords = "Biopsy, Duodenal neoplasms, Follicular lymphoma, Gastrointestinal endoscopes, Gastrointestinal lymphoma",
author = "Masaya Iwamuro and Hiroyuki Okada and Katsuyoshi Takata and Soichiro Nose and Katsuya Miyatani and Tadashi Yoshino and Kazuhide Yamamoto",
year = "2014",
doi = "10.1016/j.anndiagpath.2013.12.006",
language = "English",
volume = "18",
pages = "99--103",
journal = "Annals of Diagnostic Pathology",
issn = "1092-9134",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Diagnostic accuracy of endoscopic biopsies for the diagnosis of gastrointestinal follicular lymphoma

T2 - A clinicopathologic study of 48 patients

AU - Iwamuro, Masaya

AU - Okada, Hiroyuki

AU - Takata, Katsuyoshi

AU - Nose, Soichiro

AU - Miyatani, Katsuya

AU - Yoshino, Tadashi

AU - Yamamoto, Kazuhide

PY - 2014

Y1 - 2014

N2 - The purpose of this study was to reveal the diagnostic accuracy of initial pathologic assessment of biopsied samples in patients with gastrointestinal follicular lymphoma lesions. A total of 48 patients with follicular lymphoma (Lugano system stage I: n = 30; II1: n = 4; II2: n = 4; IV: n = 10) with gastrointestinal involvement who underwent endoscopic biopsy were enrolled and retrospectively reviewed. Nine (18.8%) of the 48 patients were not appropriately diagnosed as having follicular lymphoma at the initial biopsy. The initial pathological diagnosis included extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (n = 4), necrotic tissue (n = 2), duodenitis (n = 1), or suspected lymphoma of unspecified subtype (n = 2). The reasons for these inappropriate diagnoses were insufficient histopathologic analysis lacking CD10 and BCL2 staining (n = 7) and unsuitable biopsy samples taken from erosions or ulcers that contained scanty lymphoma cells or no lymphoid follicles (n = 2). In conclusion, incomplete histopathologic analysis and unsuitable biopsy samples are pitfalls in the diagnosis of gastrointestinal follicular lymphoma.

AB - The purpose of this study was to reveal the diagnostic accuracy of initial pathologic assessment of biopsied samples in patients with gastrointestinal follicular lymphoma lesions. A total of 48 patients with follicular lymphoma (Lugano system stage I: n = 30; II1: n = 4; II2: n = 4; IV: n = 10) with gastrointestinal involvement who underwent endoscopic biopsy were enrolled and retrospectively reviewed. Nine (18.8%) of the 48 patients were not appropriately diagnosed as having follicular lymphoma at the initial biopsy. The initial pathological diagnosis included extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (n = 4), necrotic tissue (n = 2), duodenitis (n = 1), or suspected lymphoma of unspecified subtype (n = 2). The reasons for these inappropriate diagnoses were insufficient histopathologic analysis lacking CD10 and BCL2 staining (n = 7) and unsuitable biopsy samples taken from erosions or ulcers that contained scanty lymphoma cells or no lymphoid follicles (n = 2). In conclusion, incomplete histopathologic analysis and unsuitable biopsy samples are pitfalls in the diagnosis of gastrointestinal follicular lymphoma.

KW - Biopsy

KW - Duodenal neoplasms

KW - Follicular lymphoma

KW - Gastrointestinal endoscopes

KW - Gastrointestinal lymphoma

UR - http://www.scopus.com/inward/record.url?scp=84896392567&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896392567&partnerID=8YFLogxK

U2 - 10.1016/j.anndiagpath.2013.12.006

DO - 10.1016/j.anndiagpath.2013.12.006

M3 - Article

C2 - 24513028

AN - SCOPUS:84896392567

VL - 18

SP - 99

EP - 103

JO - Annals of Diagnostic Pathology

JF - Annals of Diagnostic Pathology

SN - 1092-9134

IS - 2

ER -