Diagnosis of multiple synchronously occurring cystic jaw lesions in 23 patients: Prognostic implications related to basal cell nevus syndrome

Jun-Ichi Asaumi, Jun Murakami, Yoshinobu Yanagi, Miki Hisatomi, Hidenobu Matsuzaki, Yuu Maki, Teruhisa Unetsubo, Yasutoshi Honda, Hironobu Konouchi

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Abstract

Objectives. We rarely find multiple cystic lesions in the jaw in panoramic radiographs. Most reports of multiple cystic lesions have described keratocystic odontogenic tumors (KOTs) in patients with basal cell nevus syndrome. In this study, we performed radiographic and clinical examinations of patients with multiple cystic jaw lesions found during their first visit to our department to determine the proportion of basal cell nevus syndrome among multiple cystic lesions. Methods. Patients who had a panoramic radiograph taken at Okayama University Hospital between 1993 and 2000 were examined. Twenty-three patients with multiple cystic jaw lesions on a first panoramic radiography examination were entered into this study. Results. Of the 23 patients, 12 (52.2%) were diagnosed with basal cell nevus syndrome and 11 (47.8%) were not. Of the 14 patients with multiple KOTs, 12 (85.7%) were diagnosed as having basal cell nevus syndrome. Of the nine remaining patients with multiple cystic jaw lesions, only seven had multiple dentigerous cysts and two had multiple simple bone cysts. Cleft palate was observed in four of the 12 patients (33.3%) with basal cell nevus syndrome. Conclusion. Diagnosing basal cell nevus syndrome based on multiple cystic jaw lesions carries a high risk of misdiagnosis. A strong possibility exists that patients with multiple jaw KOTs have basal cell nevus syndrome. Furthermore, cleft palate should be considered an important oral finding in basal cell nevus syndrome because its occurrence was relatively frequent in our study.

Original languageEnglish
Pages (from-to)16-18
Number of pages3
JournalOral Radiology
Volume23
Issue number1
DOIs
Publication statusPublished - Jun 2007

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Basal Cell Nevus Syndrome
Jaw
Odontogenic Tumors
Cleft Palate
Dentigerous Cyst
Panoramic Radiography
Bone Cysts
Diagnostic Errors

Keywords

  • Basal cell nevus syndrome
  • Dentigerous cyst
  • Keratocystic odontogenic tumor
  • Multiple cystic jaw lesions
  • Simple bone cysts

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Diagnosis of multiple synchronously occurring cystic jaw lesions in 23 patients : Prognostic implications related to basal cell nevus syndrome. / Asaumi, Jun-Ichi; Murakami, Jun; Yanagi, Yoshinobu; Hisatomi, Miki; Matsuzaki, Hidenobu; Maki, Yuu; Unetsubo, Teruhisa; Honda, Yasutoshi; Konouchi, Hironobu.

In: Oral Radiology, Vol. 23, No. 1, 06.2007, p. 16-18.

Research output: Contribution to journalArticle

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abstract = "Objectives. We rarely find multiple cystic lesions in the jaw in panoramic radiographs. Most reports of multiple cystic lesions have described keratocystic odontogenic tumors (KOTs) in patients with basal cell nevus syndrome. In this study, we performed radiographic and clinical examinations of patients with multiple cystic jaw lesions found during their first visit to our department to determine the proportion of basal cell nevus syndrome among multiple cystic lesions. Methods. Patients who had a panoramic radiograph taken at Okayama University Hospital between 1993 and 2000 were examined. Twenty-three patients with multiple cystic jaw lesions on a first panoramic radiography examination were entered into this study. Results. Of the 23 patients, 12 (52.2{\%}) were diagnosed with basal cell nevus syndrome and 11 (47.8{\%}) were not. Of the 14 patients with multiple KOTs, 12 (85.7{\%}) were diagnosed as having basal cell nevus syndrome. Of the nine remaining patients with multiple cystic jaw lesions, only seven had multiple dentigerous cysts and two had multiple simple bone cysts. Cleft palate was observed in four of the 12 patients (33.3{\%}) with basal cell nevus syndrome. Conclusion. Diagnosing basal cell nevus syndrome based on multiple cystic jaw lesions carries a high risk of misdiagnosis. A strong possibility exists that patients with multiple jaw KOTs have basal cell nevus syndrome. Furthermore, cleft palate should be considered an important oral finding in basal cell nevus syndrome because its occurrence was relatively frequent in our study.",
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T2 - Prognostic implications related to basal cell nevus syndrome

AU - Asaumi, Jun-Ichi

AU - Murakami, Jun

AU - Yanagi, Yoshinobu

AU - Hisatomi, Miki

AU - Matsuzaki, Hidenobu

AU - Maki, Yuu

AU - Unetsubo, Teruhisa

AU - Honda, Yasutoshi

AU - Konouchi, Hironobu

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N2 - Objectives. We rarely find multiple cystic lesions in the jaw in panoramic radiographs. Most reports of multiple cystic lesions have described keratocystic odontogenic tumors (KOTs) in patients with basal cell nevus syndrome. In this study, we performed radiographic and clinical examinations of patients with multiple cystic jaw lesions found during their first visit to our department to determine the proportion of basal cell nevus syndrome among multiple cystic lesions. Methods. Patients who had a panoramic radiograph taken at Okayama University Hospital between 1993 and 2000 were examined. Twenty-three patients with multiple cystic jaw lesions on a first panoramic radiography examination were entered into this study. Results. Of the 23 patients, 12 (52.2%) were diagnosed with basal cell nevus syndrome and 11 (47.8%) were not. Of the 14 patients with multiple KOTs, 12 (85.7%) were diagnosed as having basal cell nevus syndrome. Of the nine remaining patients with multiple cystic jaw lesions, only seven had multiple dentigerous cysts and two had multiple simple bone cysts. Cleft palate was observed in four of the 12 patients (33.3%) with basal cell nevus syndrome. Conclusion. Diagnosing basal cell nevus syndrome based on multiple cystic jaw lesions carries a high risk of misdiagnosis. A strong possibility exists that patients with multiple jaw KOTs have basal cell nevus syndrome. Furthermore, cleft palate should be considered an important oral finding in basal cell nevus syndrome because its occurrence was relatively frequent in our study.

AB - Objectives. We rarely find multiple cystic lesions in the jaw in panoramic radiographs. Most reports of multiple cystic lesions have described keratocystic odontogenic tumors (KOTs) in patients with basal cell nevus syndrome. In this study, we performed radiographic and clinical examinations of patients with multiple cystic jaw lesions found during their first visit to our department to determine the proportion of basal cell nevus syndrome among multiple cystic lesions. Methods. Patients who had a panoramic radiograph taken at Okayama University Hospital between 1993 and 2000 were examined. Twenty-three patients with multiple cystic jaw lesions on a first panoramic radiography examination were entered into this study. Results. Of the 23 patients, 12 (52.2%) were diagnosed with basal cell nevus syndrome and 11 (47.8%) were not. Of the 14 patients with multiple KOTs, 12 (85.7%) were diagnosed as having basal cell nevus syndrome. Of the nine remaining patients with multiple cystic jaw lesions, only seven had multiple dentigerous cysts and two had multiple simple bone cysts. Cleft palate was observed in four of the 12 patients (33.3%) with basal cell nevus syndrome. Conclusion. Diagnosing basal cell nevus syndrome based on multiple cystic jaw lesions carries a high risk of misdiagnosis. A strong possibility exists that patients with multiple jaw KOTs have basal cell nevus syndrome. Furthermore, cleft palate should be considered an important oral finding in basal cell nevus syndrome because its occurrence was relatively frequent in our study.

KW - Basal cell nevus syndrome

KW - Dentigerous cyst

KW - Keratocystic odontogenic tumor

KW - Multiple cystic jaw lesions

KW - Simple bone cysts

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