TY - JOUR
T1 - Diagnosis and treatment of Ewing sarcoma of the bone
T2 - a review article
AU - Ozaki, Toshifumi
N1 - Funding Information:
This study was supported in part by the Health and Labor Sciences Research Expenses Commission; an Applied Research for Innovative Treatment of Cancer grant from the Ministry of Health, Labor, and Welfare (H26-084, H26-062); and a Grant-in-Aid for Scientific Research (B) from The Ministry of Education, Culture, Sports, Science and Technology (MEXT) (Grant Number 25293323)
Publisher Copyright:
© 2015, The Japanese Orthopaedic Association.
PY - 2015/3/30
Y1 - 2015/3/30
N2 - Ewing sarcoma (ES) is rare in Japanese people, and only 30–40 patients develop the disease annually. To diagnose ES, molecular techniques that aim to detect characteristic fusion genes are commonly used in combination with conventional histological and immunohistochemical examinations. The treatment strategy for ES is characterized by multi-disciplinary collaboration between pediatric oncologists, medical oncologists, radiation oncologists, and orthopedic surgeons. In recent years, numerous large-scale national or international multi-institutional studies of ES have been performed. Pre- and postoperative intensive systemic chemotherapy with multiple anticancer drugs is the standard treatment method for ES. Depending on the obtained surgical margin, postoperative radiation might also be performed. If preoperative radiological examinations indicate that surgical excision would be difficult, preoperative radiation can be administered. As the treatment outcomes of ES have improved, late complications and secondary malignancies have become a problem. After treatment, patients with ES require very long-term follow-up in order to detect secondary malignancies and growth-related musculoskeletal complications.
AB - Ewing sarcoma (ES) is rare in Japanese people, and only 30–40 patients develop the disease annually. To diagnose ES, molecular techniques that aim to detect characteristic fusion genes are commonly used in combination with conventional histological and immunohistochemical examinations. The treatment strategy for ES is characterized by multi-disciplinary collaboration between pediatric oncologists, medical oncologists, radiation oncologists, and orthopedic surgeons. In recent years, numerous large-scale national or international multi-institutional studies of ES have been performed. Pre- and postoperative intensive systemic chemotherapy with multiple anticancer drugs is the standard treatment method for ES. Depending on the obtained surgical margin, postoperative radiation might also be performed. If preoperative radiological examinations indicate that surgical excision would be difficult, preoperative radiation can be administered. As the treatment outcomes of ES have improved, late complications and secondary malignancies have become a problem. After treatment, patients with ES require very long-term follow-up in order to detect secondary malignancies and growth-related musculoskeletal complications.
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U2 - 10.1007/s00776-014-0687-z
DO - 10.1007/s00776-014-0687-z
M3 - Article
C2 - 25691401
AN - SCOPUS:84925498245
VL - 20
SP - 250
EP - 263
JO - Journal of Orthopaedic Science
JF - Journal of Orthopaedic Science
SN - 0949-2658
IS - 2
ER -