Diabetic nephropathy--recent advances in its mechanism and treatment

Research output: Contribution to journalArticle

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Abstract

The elevated glomerular filtration rate that occurs in 25 to 40 percent of insulin-dependent diabetics has been proposed as having a role in the initiation and evolution of diabetic nephropathy. We report that both enhanced NO synthesis by ecNOS in afferent arterioles and glomerular endothelial cells and increased expression of IGF-1 receptor can cause glomerular hyperfiltration, and that upregulated expression of ICAM-1 can promote the intraglomerular infiltration of mononuclear cells, which were prevented by aldose reductase inhibitor. The results of United Kingdom Prospective Diabetes Study (UKPDS) will also be discussed.

Original languageEnglish
Pages (from-to)590-600
Number of pages11
JournalNihon rinsho. Japanese journal of clinical medicine
Volume57
Issue number3
Publication statusPublished - 1999

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Aldehyde Reductase
IGF Type 1 Receptor
Diabetic Nephropathies
Arterioles
Intercellular Adhesion Molecule-1
Glomerular Filtration Rate
Endothelial Cells
Prospective Studies
Insulin
United Kingdom

Cite this

Diabetic nephropathy--recent advances in its mechanism and treatment. / Makino, Hirofumi; Sugimoto, H.; Shikata, Kenichi.

In: Nihon rinsho. Japanese journal of clinical medicine, Vol. 57, No. 3, 1999, p. 590-600.

Research output: Contribution to journalArticle

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