Deviated VH4 immunoglobulin gene usage is found among thyroid mucosa-associated lymphoid tissue lymphomas, similar to the usage at other sites, but is not found in thyroid diffuse large B-cell lymphomas

Yumiko Sato, Naoya Nakamura, Satoko Nakamura, Sumie Sakugawa, Koichi Ichimura, Takehiro Tanaka, Nobuya Ohara, Takashi Oka, Eisaku Kondo, Tadashi Yoshino

Research output: Contribution to journalArticle

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Abstract

It remains unclear whether or not diffuse large B-cell lymphomas of extranodal sites arise from mucosa-associated lymphoid tissue (MALT) lymphomas. We studied the clinicopathological features of MALT lymphoma and diffuse large B-cell lymphoma in the thyroid gland, with special reference to VH usage of immunoglobulin gene rearrangement, to clarify the relationships between these two types of lymphomas. In addition, t(11; 18) (q21; q21) translocation was examined by multiplex reverse transcription-polymerase chain reaction. We examined 58 patients with primary thyroid lymphoma: 31 (male seven and female 24) with MALT lymphoma and 27 (male three and female 24) with diffuse large B-cell lymphoma. Interestingly, the sequence of VH genes revealed that the two subtypes differed significantly in their use of the VH4 family (P

Original languageEnglish
Pages (from-to)1578-1584
Number of pages7
JournalModern Pathology
Volume19
Issue number12
DOIs
Publication statusPublished - Dec 15 2006

Fingerprint

Marginal Zone B-Cell Lymphoma
Immunoglobulin Genes
Lymphoma, Large B-Cell, Diffuse
Thyroid Gland
Lymphoma
Gene Rearrangement
Reverse Transcription
Polymerase Chain Reaction
Genes

Keywords

  • Diffuse large B-cell lymphoma
  • Mucosa-associated lymphoid tissue lymphoma
  • PCR
  • RT-PCR
  • Thyroid gland
  • VH family

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Deviated VH4 immunoglobulin gene usage is found among thyroid mucosa-associated lymphoid tissue lymphomas, similar to the usage at other sites, but is not found in thyroid diffuse large B-cell lymphomas. / Sato, Yumiko; Nakamura, Naoya; Nakamura, Satoko; Sakugawa, Sumie; Ichimura, Koichi; Tanaka, Takehiro; Ohara, Nobuya; Oka, Takashi; Kondo, Eisaku; Yoshino, Tadashi.

In: Modern Pathology, Vol. 19, No. 12, 15.12.2006, p. 1578-1584.

Research output: Contribution to journalArticle

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AU - Ichimura, Koichi

AU - Tanaka, Takehiro

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