Developmental dependency of Meissner corpuscles on trkB but not trkA or trkC

Hiroyuki Ichikawa, Saburo Matsuo, Inmaculada Silos-Santiago, Tomosada Sugimoto

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The distribution of S100-immunoreactive (ir) corpuscular endings was examined in the palate of wildtype and knockout mice for trkA, trkB or trkC. In wildtype mice, S100-ir corpuscular endings were abundant at the top of palatal rugae. The endings contained 2-4 parallel arrays of S100-ir neurites. The distribution of S100-ir nerve endings in trkA and trkC knockout mice was similar to that in wildtype mice; S100-ir corpuscular endings were abundant in palates of the mutant mice. In trkB knockout mice, the palate was devoid of corpuscular endings. An immunoelectron microscopic method indicated that S100-ir corpuscular endings were identical to Meissner corpuscles. The normal development of Meissner corpuscles is probably dependent on trkB but not trkA or trkC. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalNeuroReport
Volume11
Issue number2
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Mechanoreceptors
Palate
Knockout Mice
Nerve Endings
Neurites

Keywords

  • Meissner corpuscles
  • Mutant mice
  • Plate
  • trkA
  • trkB
  • trkC

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ichikawa, H., Matsuo, S., Silos-Santiago, I., & Sugimoto, T. (2000). Developmental dependency of Meissner corpuscles on trkB but not trkA or trkC. NeuroReport, 11(2), 259-262.

Developmental dependency of Meissner corpuscles on trkB but not trkA or trkC. / Ichikawa, Hiroyuki; Matsuo, Saburo; Silos-Santiago, Inmaculada; Sugimoto, Tomosada.

In: NeuroReport, Vol. 11, No. 2, 2000, p. 259-262.

Research output: Contribution to journalArticle

Ichikawa, H, Matsuo, S, Silos-Santiago, I & Sugimoto, T 2000, 'Developmental dependency of Meissner corpuscles on trkB but not trkA or trkC', NeuroReport, vol. 11, no. 2, pp. 259-262.
Ichikawa H, Matsuo S, Silos-Santiago I, Sugimoto T. Developmental dependency of Meissner corpuscles on trkB but not trkA or trkC. NeuroReport. 2000;11(2):259-262.
Ichikawa, Hiroyuki ; Matsuo, Saburo ; Silos-Santiago, Inmaculada ; Sugimoto, Tomosada. / Developmental dependency of Meissner corpuscles on trkB but not trkA or trkC. In: NeuroReport. 2000 ; Vol. 11, No. 2. pp. 259-262.
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