Abstract
To investigate the role of polyamine metabolism in fetal development, we determined the hepatic polyamine content and the activity of enzymes related to polyamine metabolism in fetal, newborn and adult rats. In the fetuses, spermidine was detected at the highest level, followed by spermine and then putrescine. Putrescine and spermidine levels were higher in the fetuses than in adult rats, while the spermine level was significantly lower in the fetuses. The activities of the enzymes investigated were also higher in the fetuses than in adult rats. These findings indicate that polyamine synthesis was enhanced in the fetal liver, and that degradation of spermidine via spermidine N'-acctyltransfcrasc contributes to the increase in putrescine levels. Thus, our study suggests that an increase in putrescine is important for fetal growth and that putrescine per se has a significant role in fetal cellular proliferation.
| Original language | English |
|---|---|
| Pages (from-to) | 402-408 |
| Number of pages | 7 |
| Journal | Neonatology |
| Volume | 62 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1992 |
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Keywords
- Decarboxylase Spermidine
- Developing rat liver
- N<sup>1</sup> –acetyltransferase
- Ornithine decarboxylase
- Polyamines
- S-Adenosylmethionine
ASJC Scopus subject areas
- Developmental Biology
- Pediatrics, Perinatology, and Child Health
Cite this
Developmental changes of polyamine biosynthesis in rat liver. / Eguchi, Katsuto; Yonezawa, Masaru; Ohmoto, Hiroyuki; Mitsui, Yukiteru; Hiramatsu, Yuji.
In: Neonatology, Vol. 62, No. 6, 1992, p. 402-408.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Developmental changes of polyamine biosynthesis in rat liver
AU - Eguchi, Katsuto
AU - Yonezawa, Masaru
AU - Ohmoto, Hiroyuki
AU - Mitsui, Yukiteru
AU - Hiramatsu, Yuji
PY - 1992
Y1 - 1992
N2 - To investigate the role of polyamine metabolism in fetal development, we determined the hepatic polyamine content and the activity of enzymes related to polyamine metabolism in fetal, newborn and adult rats. In the fetuses, spermidine was detected at the highest level, followed by spermine and then putrescine. Putrescine and spermidine levels were higher in the fetuses than in adult rats, while the spermine level was significantly lower in the fetuses. The activities of the enzymes investigated were also higher in the fetuses than in adult rats. These findings indicate that polyamine synthesis was enhanced in the fetal liver, and that degradation of spermidine via spermidine N'-acctyltransfcrasc contributes to the increase in putrescine levels. Thus, our study suggests that an increase in putrescine is important for fetal growth and that putrescine per se has a significant role in fetal cellular proliferation.
AB - To investigate the role of polyamine metabolism in fetal development, we determined the hepatic polyamine content and the activity of enzymes related to polyamine metabolism in fetal, newborn and adult rats. In the fetuses, spermidine was detected at the highest level, followed by spermine and then putrescine. Putrescine and spermidine levels were higher in the fetuses than in adult rats, while the spermine level was significantly lower in the fetuses. The activities of the enzymes investigated were also higher in the fetuses than in adult rats. These findings indicate that polyamine synthesis was enhanced in the fetal liver, and that degradation of spermidine via spermidine N'-acctyltransfcrasc contributes to the increase in putrescine levels. Thus, our study suggests that an increase in putrescine is important for fetal growth and that putrescine per se has a significant role in fetal cellular proliferation.
KW - Decarboxylase Spermidine
KW - Developing rat liver
KW - N<sup>1</sup> –acetyltransferase
KW - Ornithine decarboxylase
KW - Polyamines
KW - S-Adenosylmethionine
UR - http://www.scopus.com/inward/record.url?scp=0026613898&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026613898&partnerID=8YFLogxK
U2 - 10.1159/000243898
DO - 10.1159/000243898
M3 - Article
C2 - 1472582
AN - SCOPUS:0026613898
VL - 62
SP - 402
EP - 408
JO - Neonatology
JF - Neonatology
SN - 1661-7800
IS - 6
ER -