Developmental changes of polyamine biosynthesis in rat liver

Katsuto Eguchi, Masaru Yonezawa, Hiroyuki Ohmoto, Yukiteru Mitsui, Yuji Hiramatsu

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

To investigate the role of polyamine metabolism in fetal development, we determined the hepatic polyamine content and the activity of enzymes related to polyamine metabolism in fetal, newborn and adult rats. In the fetuses, spermidine was detected at the highest level, followed by spermine and then putrescine. Putrescine and spermidine levels were higher in the fetuses than in adult rats, while the spermine level was significantly lower in the fetuses. The activities of the enzymes investigated were also higher in the fetuses than in adult rats. These findings indicate that polyamine synthesis was enhanced in the fetal liver, and that degradation of spermidine via spermidine N'-acctyltransfcrasc contributes to the increase in putrescine levels. Thus, our study suggests that an increase in putrescine is important for fetal growth and that putrescine per se has a significant role in fetal cellular proliferation.

Original languageEnglish
Pages (from-to)402-408
Number of pages7
JournalNeonatology
Volume62
Issue number6
DOIs
Publication statusPublished - Jan 1 1992

Keywords

  • Decarboxylase Spermidine
  • Developing rat liver
  • N<sup>1</sup> –acetyltransferase
  • Ornithine decarboxylase
  • Polyamines
  • S-Adenosylmethionine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

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