Developmental Aspects of Epilepsy with Special Reference to Age‐Dependent Epileptic Encephalopathy

Yoko Ohtsuka; Tatsuya Ogino; Nagako Murakami; Nobuyoshi Mimaki; Katsuhiro Kobayashi; Shunsuke Ohtahara

doi:10.1111/j.1440-1819.1986.tb03152.x

Developmental Aspects of Epilepsy with Special Reference to Age‐Dependent Epileptic Encephalopathy

Yoko Ohtsuka, Tatsuya Ogino, Nagako Murakami, Nobuyoshi Mimaki, Katsuhiro Kobayashi, Shunsuke Ohtahara

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Abstract: The specificity of childhood epilepsy was characterized by investigating the evolutional changes with age and prognoses of age‐dependent epileptic encephalopathy from the developmental aspect through a long‐term follow‐up. Three types of age‐dependent epileptic encephalopathy showed mutual evolutional changes at certain ages. This indicated an important role of the brain development in the clinicoelectroencephalographical manifestations of age‐dependent epileptic encephalopathy. Furthermore, the evolutional changes demonstrated an association with organic brain damage and etiology in addition to the age factors. The evolutional changes occurred more frequently in the cases with overt organic brain pathology. The prognosis was poorer in cases which underwent an evolutional change.

Original language	English
Pages (from-to)	307-313
Number of pages	7
Journal	Psychiatry and Clinical Neurosciences
Volume	40
Issue number	3
DOIs	https://doi.org/10.1111/j.1440-1819.1986.tb03152.x
Publication status	Published - Sep 1986

Keywords

Lennox‐Gastaut syndrome
West syndrome
age factor
development
early‐infantile epileptic encephalopathy with suppression‐burst
epilepsy

ASJC Scopus subject areas

Neuroscience(all)
Neurology
Clinical Neurology
Psychiatry and Mental health

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title = "Developmental Aspects of Epilepsy with Special Reference to Age‐Dependent Epileptic Encephalopathy",

abstract = "Abstract: The specificity of childhood epilepsy was characterized by investigating the evolutional changes with age and prognoses of age‐dependent epileptic encephalopathy from the developmental aspect through a long‐term follow‐up. Three types of age‐dependent epileptic encephalopathy showed mutual evolutional changes at certain ages. This indicated an important role of the brain development in the clinicoelectroencephalographical manifestations of age‐dependent epileptic encephalopathy. Furthermore, the evolutional changes demonstrated an association with organic brain damage and etiology in addition to the age factors. The evolutional changes occurred more frequently in the cases with overt organic brain pathology. The prognosis was poorer in cases which underwent an evolutional change.",

keywords = "Lennox‐Gastaut syndrome, West syndrome, age factor, development, early‐infantile epileptic encephalopathy with suppression‐burst, epilepsy",

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AU - Ohtsuka, Yoko

AU - Ogino, Tatsuya

AU - Murakami, Nagako

AU - Mimaki, Nobuyoshi

AU - Kobayashi, Katsuhiro

AU - Ohtahara, Shunsuke

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