Development of tubulin-polymerization inhibitors based on the thalidomide skeleton

Hiroshi Aoyama, Tomomi Noguchi, Takashi Misawa, Takanori Nakamura, Hiroyuki Miyachi, Yuichi Hashimoto, Hisayoshi Kobayashi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


We synthesized a series of compounds based on the potent tubulin-polymerization inhibitor 5-hydroxy-2-(2,6-diisopropylphenyl)-1H- isoindole-1,3-dione [5HPP-33 (3)], which is structurally derived from thalidomide (1), and investigated their inhibitory effects on tubulin polymerization. Direct interaction between 5HPP-33 (3) and α,β- tubulin heterodimer protein was demonstrated by means of a surface plasmon resonance study.

Original languageEnglish
Pages (from-to)944-949
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Issue number6
Publication statusPublished - Jun 2007


  • Phthalimide skeleton
  • Surface plasmon resonance
  • Thalidomide
  • Tubulin polymerization inhibitor

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery


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