We synthesized a series of compounds based on the potent tubulin-polymerization inhibitor 5-hydroxy-2-(2,6-diisopropylphenyl)-1H- isoindole-1,3-dione [5HPP-33 (3)], which is structurally derived from thalidomide (1), and investigated their inhibitory effects on tubulin polymerization. Direct interaction between 5HPP-33 (3) and α,β- tubulin heterodimer protein was demonstrated by means of a surface plasmon resonance study.
- Phthalimide skeleton
- Surface plasmon resonance
- Tubulin polymerization inhibitor
ASJC Scopus subject areas
- Drug Discovery