Development of practical synthesis of halichondrins

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Abstract

Halichondrin B is a polyether macrolide that exhibits an extraordinary cytotoxicity in vitro and antitumor efficacy in vivo. A structurally simplified macrolactone right half segment of harichondrin B was identified to retain the potent cell growth inhibitory activity of the natural product in vitro. Kishi and coworkers developed a practical, an efficient and scalable synthesis of the right half segment of harichondrin B.

Original languageEnglish
Pages (from-to)1225-1226
Number of pages2
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume65
Issue number12
Publication statusPublished - Dec 2007
Externally publishedYes

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ASJC Scopus subject areas

  • Organic Chemistry

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