Development of microspheres covered with hydroxyapatite nanocrystals as cell scaffold for angiogenesis

Takashi Iwamoto, Takahiro Terada, Yasumichi Kogai, Masahiro Okada, Syuji Fujii, Tsutomu Furuzono

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We prepared poly(L-lactide-co-glycolide) cell scaffolds coated with hydroxyapatite (HAp) nanocrystals with 50100 nm in diameter via the Pickering emulsion method. Our cell scaffolds were composed of biodegradable polymers and HAp nanocrystals as a core and shell, respectively. The scaffolds were spherical but displayed uneven shapes when altering a shear speed of homogenization during syntheses. The surface coverage of HAp nanocrystals was examined because the HAp-coating ratio for the scaffolds was an important factor as cell scaffolds in order to enhance cell adhesion. On the basis of scanning electron microscopy observations and thermogravimetric analyses, it was found that the cell scaffolds showed distorted morphologies, and the HAp-coating ratio decreased with increasing the shear speed in the synthesis because shear stress influenced shapes of the scaffolds.

Original languageEnglish
Article number1260010
JournalFunctional Materials Letters
Volume5
Issue number2
DOIs
Publication statusPublished - Jun 1 2012
Externally publishedYes

Keywords

  • Hydroxyapatite
  • Pickering emulsion
  • biodegradable polymer
  • cell scaffold
  • surface coverage

ASJC Scopus subject areas

  • Materials Science(all)

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