Development of invasive colon cancer with microsatellite instability in a patient with hyperplastic polyposis syndrome

Joichiro Horii, Jun Kato, Takeshi Nagasaka, Sakiko Hiraoka, Dong Sheng Sun, Kazuo Watanabe, Isao Fujita, Tatsuya Toyokawa, Jun Tomoda, Kazuhide Yamamoto

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The serrated pathway has recently been proposed as a route for the development of colorectal cancer with microsatellite instability. Hyperplastic polyposis syndrome is a rare syndrome defined by the presence of numerous serrated polyps, with a high risk of developing into colorectal cancer. We present here a case of hyperplastic polyposis syndrome developing into colorectal cancer with microsatellite instability from a serrated polyp. BRAF mutation and the loss of MLH1 protein were observed in the colorectal cancer, but not in the other serrated polyps around the colorectal cancer, suggesting that colorectal cancer with microsatellite instability develops rapidly from a specific serrated polyp with distinct molecular properties.

Original languageEnglish
Article numberhys031
Pages (from-to)451-454
Number of pages4
JournalJapanese journal of clinical oncology
Volume42
Issue number5
DOIs
Publication statusPublished - May 2012

Keywords

  • BRAF mutation
  • Colorectal cancer
  • Hyperplastic polyposis
  • Microsatellite instability
  • Serrated pathway

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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  • Cite this

    Horii, J., Kato, J., Nagasaka, T., Hiraoka, S., Sun, D. S., Watanabe, K., Fujita, I., Toyokawa, T., Tomoda, J., & Yamamoto, K. (2012). Development of invasive colon cancer with microsatellite instability in a patient with hyperplastic polyposis syndrome. Japanese journal of clinical oncology, 42(5), 451-454. [hys031]. https://doi.org/10.1093/jjco/hys031