Development of injection containers for patient and medical Staff

Yoichi Kawasaki, Toshiaki Sendo

Research output: Contribution to journalReview articlepeer-review


Recently, there has been a transition from glass to plastic injection containers in Japan. In our previous study, we suggested that plastic containers had less impurity contamination than glass containers. However, the use of some plasticizers has been limited because of their endocrine disrupting effects. Therefore, contamination has been a concern due to chemicals in injection solution packed with plastic containers. Indeed, in our recent study, photoinitiators were detected in an injection solution coming from plastic containers. Photoinitiators mainly exist in ink. We therefore speculated that ink originating from a photoinitiator directly printing on plastic containers had migrated into the injection solutions. In a clinical setting, plastic containers are very tractable because they are lightweight and less breakable. On the other hand, from a safety view point, these containers may be hazardous because of permeation by steam, ambient air or photoinitiators. In the present symposium, we will discuss the risk of photoinitiators leaking into injection solution packed with plastic containers, and countermeasures to avoid this risk.

Original languageEnglish
Pages (from-to)255-262
Number of pages8
JournalYakugaku Zasshi
Issue number2
Publication statusPublished - Feb 1 2015
Externally publishedYes


  • Cytotoxicity
  • Endocrine disrupting effect
  • Permeation
  • Photoinitiator
  • Plastic injection container
  • Trade-off

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science


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