Development of hepatocellular carcinoma in a woman with HBV- and HCV-negative autoimmune hepatitis with unsatisfactory response to corticosteroid

Yasuhiro Miyake, Kohsaku Sakaguchi, Hironori Tanaka, Shinichiro Nakamura, Yoshiyuki Kobayashi, Shin Ichi Fujioka, Yoshiaki Iwasaki, Yasushi Shiratori

Research output: Contribution to journalArticle

10 Citations (Scopus)


A 57-year-old woman was admitted due to a hemorrhage from esophageal varices. Laboratory tests showed liver dysfunction, elevated immunoglobulin G levels and positivity for anti-nuclear antibodies. Serum hepatitis B virus and hepatitis C virus markers were negative. The liver biopsy specimen was compatible with autoimmune hepatitis, and low-dose prednisolone was started. During the follow-up, her serum alanine aminotransferase levels continued to fluctuate between 40 and 60 IU/l. Nine years later, hepatocellular carcinoma 20 mm in diameter was detected. This case suggests that hepatocellular carcinoma develops even if serum alanine aminotransferase levels are maintained at less than twice the upper normal limit.

Original languageEnglish
Pages (from-to)949-953
Number of pages5
JournalInternal Medicine
Issue number9
Publication statusPublished - Oct 28 2005



  • Alanine aminotransferase
  • Autoimmune hepatitis
  • Corticosteroid treatment
  • Hepatocellular carcinoma

ASJC Scopus subject areas

  • Internal Medicine

Cite this