Development of bisphosphonate-calcium phosphate composites and drug release characteristic

Hidekuni Kameda, Tomohiko Yoshioka, Toshiyuki Ikoma, Junzo Tanaka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Bisphosphonate (Bp) was adsorbed on the surface of crystalline calcium phosphates (CP); hydroxyapatite (HAp), octacalcium phosphate (OCP) and Dicalcium phosphate dehydrate (DCPD). The amount of Bp adsorbed was the largest for DCPD per unit surface area, while the amount was the largest for HAp per unit weight. The composites of Bp and amorphous calcium phosphate (ACP) were synthesized by titrating calcium acetate solution into phosphate buffer solution containing Bp. The amount of Bp doped in the composites was 366 μg/mg and was approximately 7 times larger than those of Bp adsorbed on the crystalline Calcium phosphates. TG-DTA measurements of a Bp-calcium and the composite indicated exothermic peaks due to Bp combustion, of which temperature were shifted to higher temperature for the composite. Bp in the composites was gradually released into phosphate buffered saline, while Bp was rapidly released into acetate buffer solution accompanied with the dissolution of ACP. This result suggests that the composite of Bp and ACP has potential for a drug-carrier releasing Bp in response to the condition of osteoclastic bone resorption.

Original languageEnglish
Title of host publicationMaterials Research Society Symposium Proceedings
Pages209-214
Number of pages6
Volume1418
DOIs
Publication statusPublished - 2012
Externally publishedYes
Event2011 MRS Fall Meeting - Boston, MA, United States
Duration: Nov 28 2011Dec 2 2011

Other

Other2011 MRS Fall Meeting
CountryUnited States
CityBoston, MA
Period11/28/1112/2/11

Fingerprint

calcium phosphates
Diphosphonates
Calcium phosphate
drugs
phosphates
Phosphates
composite materials
Composite materials
Pharmaceutical Preparations
Hydroxyapatite
calcium
acetates
Calcium
buffers
Calcium Phosphates
Crystalline materials
calcium acetate
releasing
Durapatite
Differential thermal analysis

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

Cite this

Kameda, H., Yoshioka, T., Ikoma, T., & Tanaka, J. (2012). Development of bisphosphonate-calcium phosphate composites and drug release characteristic. In Materials Research Society Symposium Proceedings (Vol. 1418, pp. 209-214) https://doi.org/10.1557/opl.2012.713

Development of bisphosphonate-calcium phosphate composites and drug release characteristic. / Kameda, Hidekuni; Yoshioka, Tomohiko; Ikoma, Toshiyuki; Tanaka, Junzo.

Materials Research Society Symposium Proceedings. Vol. 1418 2012. p. 209-214.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kameda, H, Yoshioka, T, Ikoma, T & Tanaka, J 2012, Development of bisphosphonate-calcium phosphate composites and drug release characteristic. in Materials Research Society Symposium Proceedings. vol. 1418, pp. 209-214, 2011 MRS Fall Meeting, Boston, MA, United States, 11/28/11. https://doi.org/10.1557/opl.2012.713
Kameda H, Yoshioka T, Ikoma T, Tanaka J. Development of bisphosphonate-calcium phosphate composites and drug release characteristic. In Materials Research Society Symposium Proceedings. Vol. 1418. 2012. p. 209-214 https://doi.org/10.1557/opl.2012.713
Kameda, Hidekuni ; Yoshioka, Tomohiko ; Ikoma, Toshiyuki ; Tanaka, Junzo. / Development of bisphosphonate-calcium phosphate composites and drug release characteristic. Materials Research Society Symposium Proceedings. Vol. 1418 2012. pp. 209-214
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