Development of bioresorbable calcium-Phosphate cements hybridized with gelatin particles and their in vivo evaluation using pig's tibia model

Keishi Kiminami, Kento Matsuoka, Kohei Nagata, Toshiisa Konishi, Michiyo Honda, Gota Hayashida, Kazuaki Nakano, Masaki Nagaya, Hidetoshi Arimura, Hiroshi Nagashima, Mamoru Aizawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Novel bioresorbable calcium-phosphate cement (CPC) with anti-washout property was developed by adding thermally cross-linked gelatin particles as pore generator into a CPC. The CPC was composed of α-tricalcium phosphate (α-TCP) and surface-modified hydroxyapatite (HAp) with inositol phosphate as a chelating agent (IP6-HAp). The bioresorbable CPC hybridized with gelatin particles was successfully fabricated by mixing the aqueous sodium chondroitin sulfate solution including Na2HPO4 and the pre-mixed powders composed of α-TCP (72 mass%), IP6-HAp (18 mass%), and the gelatin particles (10 mass%). The hybridized CPC paste showed initial setting time (IST) of 5 minutes and exhibited anti-washout property. Compressive strength after setting for 24 h reached to 4.2 MPa. An in vivo preliminary study using pig's tibia model demonstrated that the hybridized CPC could be easily injected and set promptly without washout. In addition, no fragmentation in the specimens was observed after 8 weeks implantation. Moreover, histological observation (Villanueva bone stain) revealed that almost 80% of the hybridized CPC specimens were resorbed and that immature bones were formed inside the specimens.

Original languageEnglish
Title of host publicationBioceramics 26
EditorsMaria-Pau Ginebra, Cristina Canal, Montserrat Espanol, Edgar B. Montufar, Roman A. Perez
PublisherTrans Tech Publications Ltd
Pages397-401
Number of pages5
ISBN (Electronic)9783038352822
DOIs
Publication statusPublished - Jan 1 2015
Event26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, ISCM 2014 - Barcelona, Spain
Duration: Nov 6 2014Nov 8 2014

Publication series

NameKey Engineering Materials
Volume631
ISSN (Print)1013-9826

Other

Other26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, ISCM 2014
CountrySpain
CityBarcelona
Period11/6/1411/8/14

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Keywords

  • Bioresorbability
  • Calcium-phosphate cement
  • Chelate-setting cement
  • Gelatin particles
  • In vivo evaluation

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Kiminami, K., Matsuoka, K., Nagata, K., Konishi, T., Honda, M., Hayashida, G., Nakano, K., Nagaya, M., Arimura, H., Nagashima, H., & Aizawa, M. (2015). Development of bioresorbable calcium-Phosphate cements hybridized with gelatin particles and their in vivo evaluation using pig's tibia model. In M-P. Ginebra, C. Canal, M. Espanol, E. B. Montufar, & R. A. Perez (Eds.), Bioceramics 26 (pp. 397-401). (Key Engineering Materials; Vol. 631). Trans Tech Publications Ltd. https://doi.org/10.4028/www.scientific.net.KEM.631.397