Development of animal models of treatment-resistant depression of rats

Yoshihisa Kitamura, Yutaka Gomita

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Psychoendocrinological studies have focused on the hypothalamic-pituitary- adrenal axis in patients with depression. We have already reported that in rats, repeated adrenocorticotropic hormone (ACTH) treatment blocks the effect of tricyclic antidepressants in decreasing immobility time in a forced swim test, a widely used animal experiment for predicting antidepressant activity. Furthermore, chronic coadministration of lithium or carbamazepine, an agent that potentiates the actions of antidepressants in patients with depression, including those with treatment-resistant depression, significantly decreased the duration of immobility, even when given concurrently with ACTH. Recently, clinical and animal studies have shown that neurogenesis/neuroprotection in the adult brain is important for the therapeutic actions of antidepressants. We indicated that repeated ACTH treatment decreased the expression of BDNFmRNA and the number of newborn cells in the rat hippocampus. Namely, we rec-ognized that ACTH-treated rats served as a useful animal model of tricyclic antidepressant treatment-resistant conditions.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalJapanese Journal of Neuropsychopharmacology
Volume28
Issue number2
Publication statusPublished - Apr 2008

Fingerprint

Treatment-Resistant Depressive Disorder
Adrenocorticotropic Hormone
Animal Models
Antidepressive Agents
Tricyclic Antidepressive Agents
Depression
Neurogenesis
Carbamazepine
Therapeutics
Lithium
Hippocampus
Cell Count
Newborn Infant
Brain

Keywords

  • Adult neurogenesis
  • Animal model
  • BDNF
  • HPA axis
  • Treatment-resistant depression

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Development of animal models of treatment-resistant depression of rats. / Kitamura, Yoshihisa; Gomita, Yutaka.

In: Japanese Journal of Neuropsychopharmacology, Vol. 28, No. 2, 04.2008, p. 93-100.

Research output: Contribution to journalArticle

@article{93075fd4c09745e49e9bab16502c00c7,
title = "Development of animal models of treatment-resistant depression of rats",
abstract = "Psychoendocrinological studies have focused on the hypothalamic-pituitary- adrenal axis in patients with depression. We have already reported that in rats, repeated adrenocorticotropic hormone (ACTH) treatment blocks the effect of tricyclic antidepressants in decreasing immobility time in a forced swim test, a widely used animal experiment for predicting antidepressant activity. Furthermore, chronic coadministration of lithium or carbamazepine, an agent that potentiates the actions of antidepressants in patients with depression, including those with treatment-resistant depression, significantly decreased the duration of immobility, even when given concurrently with ACTH. Recently, clinical and animal studies have shown that neurogenesis/neuroprotection in the adult brain is important for the therapeutic actions of antidepressants. We indicated that repeated ACTH treatment decreased the expression of BDNFmRNA and the number of newborn cells in the rat hippocampus. Namely, we rec-ognized that ACTH-treated rats served as a useful animal model of tricyclic antidepressant treatment-resistant conditions.",
keywords = "Adult neurogenesis, Animal model, BDNF, HPA axis, Treatment-resistant depression",
author = "Yoshihisa Kitamura and Yutaka Gomita",
year = "2008",
month = "4",
language = "English",
volume = "28",
pages = "93--100",
journal = "Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology",
issn = "1340-2544",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Development of animal models of treatment-resistant depression of rats

AU - Kitamura, Yoshihisa

AU - Gomita, Yutaka

PY - 2008/4

Y1 - 2008/4

N2 - Psychoendocrinological studies have focused on the hypothalamic-pituitary- adrenal axis in patients with depression. We have already reported that in rats, repeated adrenocorticotropic hormone (ACTH) treatment blocks the effect of tricyclic antidepressants in decreasing immobility time in a forced swim test, a widely used animal experiment for predicting antidepressant activity. Furthermore, chronic coadministration of lithium or carbamazepine, an agent that potentiates the actions of antidepressants in patients with depression, including those with treatment-resistant depression, significantly decreased the duration of immobility, even when given concurrently with ACTH. Recently, clinical and animal studies have shown that neurogenesis/neuroprotection in the adult brain is important for the therapeutic actions of antidepressants. We indicated that repeated ACTH treatment decreased the expression of BDNFmRNA and the number of newborn cells in the rat hippocampus. Namely, we rec-ognized that ACTH-treated rats served as a useful animal model of tricyclic antidepressant treatment-resistant conditions.

AB - Psychoendocrinological studies have focused on the hypothalamic-pituitary- adrenal axis in patients with depression. We have already reported that in rats, repeated adrenocorticotropic hormone (ACTH) treatment blocks the effect of tricyclic antidepressants in decreasing immobility time in a forced swim test, a widely used animal experiment for predicting antidepressant activity. Furthermore, chronic coadministration of lithium or carbamazepine, an agent that potentiates the actions of antidepressants in patients with depression, including those with treatment-resistant depression, significantly decreased the duration of immobility, even when given concurrently with ACTH. Recently, clinical and animal studies have shown that neurogenesis/neuroprotection in the adult brain is important for the therapeutic actions of antidepressants. We indicated that repeated ACTH treatment decreased the expression of BDNFmRNA and the number of newborn cells in the rat hippocampus. Namely, we rec-ognized that ACTH-treated rats served as a useful animal model of tricyclic antidepressant treatment-resistant conditions.

KW - Adult neurogenesis

KW - Animal model

KW - BDNF

KW - HPA axis

KW - Treatment-resistant depression

UR - http://www.scopus.com/inward/record.url?scp=44449155533&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44449155533&partnerID=8YFLogxK

M3 - Article

C2 - 18516988

AN - SCOPUS:44449155533

VL - 28

SP - 93

EP - 100

JO - Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology

JF - Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology

SN - 1340-2544

IS - 2

ER -